(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

Base Information

Chemical Name:(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine
CAS No.:149672-51-5
Molecular Formula:C₄₂H₅₁N₄O₈P
Molecular Weight:770.863
Hs Code.:

(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

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Technology Process of (3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

There total 5 articles about (3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

: 124482-92-4,89992-70-1
2-cyanoethyl-N,N-(diisopropylamino)chlorophosphine

: 149672-47-9
(3'S,5'R)-1-<2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

: 149672-51-5,160707-00-6,160707-01-7
(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 1h; Ambient temperature;

Reference yield:

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 149672-51-5,160707-00-6,160707-01-7
(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / tetrahydrofuran / 1 h

2: 88 percent / pyridine / 5.25 h

3: 63 percent / (i-Pr)2EtN / tetrahydrofuran

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.19940770315

Reference yield:

: (4,4'-dimethoxytriphenyl)methyl trifluoromethanesulfonate

: 149672-51-5,160707-00-6,160707-01-7
(3'S,5'R)-1-<3'-O-<(2-cyanoethoxy)(diisopropylamino)phosphino>-2'-deoxy-5'-O-<(4,4'-dimethoxytriphenyl)methyl>-3',5'-ethano-β-D-ribofuranosyl>thymine

Guidance literature:: Multi-step reaction with 2 steps

1: 88 percent / pyridine / 5.25 h

2: 63 percent / (i-Pr)2EtN / tetrahydrofuran

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; pyridine;
DOI:10.1002/hlca.19940770315