Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Name:Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester
CAS No.:195304-72-4
Molecular Formula:C₄₉H₄₂FN₁₄O₁₃P
Molecular Weight:1084.93
Hs Code.:

Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Chemical Property of Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

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Technology Process of Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

There total 6 articles about Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₆₉H₅₈FN₁₄O₁₄P

: 195304-72-4
Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: With toluene-4-sulfonic acid; In methanol; dichloromethane; for 0.166667h; Yield given;
DOI:10.1002/hlca.19980810538

Reference yield:

: 123334-78-1
2'-azido-2',3'-dideoxy-3'-fluoroadenosine

: 195304-72-4
Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: pyridine / 4 h / Ambient temperature

2: 2.) conc.NH₄OH, H₂O / 1.) pyridine, r.t., 0.5 h

3: 1H-tetrazole, 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 20 h / Ambient temperature

4: 2percent TsOH / CH₂Cl₂; methanol / 0.17 h

With 1H-tetrazole; ammonium hydroxide; 2,4,6-triisopropylphenylsulfonyl chloride; water; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19980810538

Reference yield:

: C₅₂H₄₄N₆O₁₂P^(1-)

: 195304-72-4
Benzoic acid (2R,3R,4R,5R)-4-{[(2R,3S,4S,5R)-4-azido-5-(6-benzoylamino-purin-9-yl)-3-fluoro-tetrahydro-furan-2-ylmethoxy]-[2-(4-nitro-phenyl)-ethoxy]-phosphoryloxy}-5-(6-benzoylamino-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1H-tetrazole, 2,4,6-triisopropylbenzenesulfonyl chloride / pyridine / 20 h / Ambient temperature

2: 2percent TsOH / CH₂Cl₂; methanol / 0.17 h

With 1H-tetrazole; 2,4,6-triisopropylphenylsulfonyl chloride; toluene-4-sulfonic acid; In pyridine; methanol; dichloromethane;
DOI:10.1002/hlca.19980810538