C₂₁H₂₈N₈O

Base Information

• Chemical Name: C₂₁H₂₈N₈O
• CAS No.: 1383810-38-5
• Molecular Formula: C₂₁H₂₈N₈O
• Molecular Weight: 408.506
• Mol file: 1383810-38-5.mol

Synonyms:

Chemical Property of C₂₁H₂₈N₈O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₈N₈O

There total 6 articles about C₂₁H₂₈N₈O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C13H17ClN6O2 (439803-59-5) → C21H28N8O (1383810-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: toluene-4-sulfonic acid / tetrahydrofuran / Reflux

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 80 - 100 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

4: sodium hydroxide / tetrahydrofuran; methanol

With hydrogenchloride; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 2: Buchwald coupling;

DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

4-(3-methyl-4-nitrophenyl)morpholine (220679-09-4) → C21H28N8O (1383810-38-5)

Guidance literature:

Multi-step reaction with 4 steps

1: palladium 10% on activated carbon; hydrogen / methanol

2: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 80 - 100 °C

3: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

4: sodium hydroxide / tetrahydrofuran; methanol

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; toluene; 2: Buchwald coupling;

DOI:10.1016/j.bmcl.2012.04.131

Reference yield:

ethyl 4-aminopiperidine-1-carboxylate (58859-46-4) → C21H28N8O (1383810-38-5)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine / ethanol / 80 °C

2: toluene-4-sulfonic acid / tetrahydrofuran / Reflux

3: palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / toluene / 80 - 100 °C

4: hydrogenchloride / 1,4-dioxane; methanol / 20 °C

5: sodium hydroxide / tetrahydrofuran; methanol

With hydrogenchloride; palladium diacetate; caesium carbonate; toluene-4-sulfonic acid; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; sodium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; toluene; 3: Buchwald coupling;

DOI:10.1016/j.bmcl.2012.04.131

upstream raw materials:

C₁₃H₁₇ClN₆O₂

C₁₈H₂₅ClN₆O₃

C₂₉H₄₀N₈O₄

2-Methyl-4-morpholin-4-ylphenylamine

Refernces