isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

Base Information

Chemical Name:isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate
CAS No.:128053-56-5
Molecular Formula:C₃₈H₅₁N₅O₇
Molecular Weight:689.852
Hs Code.:

isopropyl (2R,3R)-3-<<N-<(2R)-3-(morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl>-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

Chemical Property:

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Technology Process of isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

There total 9 articles about isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125702-08-1
2-(1-Naphthylmethylidene)succinic Acid

: 128053-56-5
isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 4 steps

2: dicyclohexylcarbodiimide (DCC), N-hydroxy-5-norbornene-2,3-dicarboximide (HONB) / 1.) 0 deg C, 2 h, 2.) RT, 20 h

3: 1N NaOH / methanol / 1.) 0 deg C, 2 h, 2.) RT, 20 h

4: dicyclohexylcarbodiimide (DCC), N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), triethylamine / acetonitrile / 1.) 0 deg C, 2 h, 2.) RT, 18 h

With sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1021/jm00172a005

Reference yield:

: 113724-12-2
N-[(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionyl]-L-histidine Methyl Ester

: 128053-56-5
isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 2 steps

1: 1N NaOH / methanol / 1.) 0 deg C, 2 h, 2.) RT, 20 h

2: dicyclohexylcarbodiimide (DCC), N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), triethylamine / acetonitrile / 1.) 0 deg C, 2 h, 2.) RT, 18 h

With sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1021/jm00172a005

Reference yield:

: 119434-65-0
(2R)-3-(Morpholinocarbonyl)-2-(1-naphthylmethyl)-propionic acid

: 128053-56-5
isopropyl (2R,3R)-3-<-L-histidyl>amino>-4-cyclohexyl-2-hydroxybutyrate

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide (DCC), N-hydroxy-5-norbornene-2,3-dicarboximide (HONB) / 1.) 0 deg C, 2 h, 2.) RT, 20 h

2: 1N NaOH / methanol / 1.) 0 deg C, 2 h, 2.) RT, 20 h

3: dicyclohexylcarbodiimide (DCC), N-hydroxy-5-norbornene-2,3-dicarboximide (HONB), triethylamine / acetonitrile / 1.) 0 deg C, 2 h, 2.) RT, 18 h

With sodium hydroxide; N-hydroxy-5-norbornene-2,3-dicarboximide; triethylamine; dicyclohexyl-carbodiimide; In methanol; acetonitrile;
DOI:10.1021/jm00172a005