{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

Base Information

Chemical Name:{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester
CAS No.:871566-23-3
Molecular Formula:C₂₅H₂₂N₂O₁₀
Molecular Weight:510.457
Hs Code.:

{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

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Chemical Property of {[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

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Technology Process of {[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

There total 7 articles about {[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: (E)-4-(4-Nitro-phenyl)-4-oxo-but-2-enoic acid (2R,3R)-5-(benzyloxycarbonylmethyl-carbamoyl)-2-methoxy-2,3-dihydro-furan-3-yl ester

: 871566-23-3
{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

: 1070773-35-1
C₁₅H₁₅NO₅

Guidance literature:: With lithium perchlorate; In acetonitrile; at 50 ℃; for 72h; Further Variations:; Solvents; Temperatures; Kinetics;
DOI:10.1080/15257770701490704

Reference yield: 44.0%

: (E)-4-(4-Nitro-phenyl)-4-oxo-but-2-enoic acid (2R,3R)-5-(benzyloxycarbonylmethyl-carbamoyl)-2-methoxy-2,3-dihydro-furan-3-yl ester

: 871566-23-3
{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

Guidance literature:: In toluene; at 100 ℃; for 24h;
DOI:10.1055/s-2005-872684

Reference yield:

: C₁₅H₁₅NO₆

: 871566-23-3
{[(2R,2aR,4aR,7aS,7bS)-2-Methoxy-6-(4-nitro-phenyl)-4-oxo-2a,4,4a,7b-tetrahydro-2H-1,3,7-trioxa-cyclopenta[cd]indene-7a-carbonyl]-amino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dimethyl-4-aminopyridine / CH₂Cl₂ / 2 h / 0 °C

2: 44 percent / toluene / 24 h / 100 °C

With dmap; In dichloromethane; toluene;
DOI:10.1055/s-2005-872684