(E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide

Base Information

• Chemical Name: (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide
• CAS No.: 1174570-26-3
• Molecular Formula: C₂₆H₂₅F₃N₄O₃
• Molecular Weight: 498.505
• Mol file: 1174570-26-3.mol

Synonyms:

Chemical Property of (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide

There total 10 articles about (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C25H31N3O6 → (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide (1174570-26-3)

Guidance literature:

Multi-step reaction with 3 steps

1: lithium hydroxide monohydrate / methanol / 5 h / 20 °C

2: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

3: hydrogenchloride / methanol

With hydrogenchloride; lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane;

DOI:10.1021/jm3011838

Reference yield:

4-bromo-DL-mandelic acid (6940-50-7) → (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide (1174570-26-3)

Guidance literature:

Multi-step reaction with 7 steps

1: sulfuric acid / 3 h / 50 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; triethylamine; tris-(o-tolyl)phosphine / N,N-dimethyl-formamide / 6 h / 100 °C / Inert atmosphere

3: triethylamine / dichloromethane / 1 h / -5 - 0 °C / Inert atmosphere

4: triethylamine / dichloromethane / 16 h / 20 °C

5: lithium hydroxide monohydrate / methanol / 5 h / 20 °C

6: N-ethyl-N,N-diisopropylamine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate / dichloromethane / 12 h / 20 °C

7: hydrogenchloride / methanol

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; sulfuric acid; triethylamine; N-ethyl-N,N-diisopropylamine; tris-(o-tolyl)phosphine; bromo-tris(1-pyrrolidinyl)phosphonium hexafluorophosphate; In methanol; dichloromethane; N,N-dimethyl-formamide; 2: |Heck Reaction;

DOI:10.1021/jm3011838

Reference yield:

C31H33F3N4O5 → (E)-N-(2-aminophenyl)-3-{4-[(2-hydroxyethylamino)(4-trifluoromethylphenylcarbamoyl)methyl]phenyl}acrylamide (1174570-26-3)

Guidance literature:

C₃₁H₃₃F₃N₄O₅; With hydrogenchloride; In methanol;

With sodium hydrogencarbonate; In methanol;

DOI:10.1021/jm3011838

upstream raw materials:

4-trifluoromethylphenylamine

C₂₄H₂₉N₃O₆

4-bromo-DL-mandelic acid

α-hydroxy-(p-bromophenyl)-acetic acid methyl ester