C₁₄H₁₁ClN₂O

Base Information

• Chemical Name: C₁₄H₁₁ClN₂O
• CAS No.: 481049-37-0
• Molecular Formula: C₁₄H₁₁ClN₂O
• Molecular Weight: 258.707
• Mol file: 481049-37-0.mol

Synonyms:

Chemical Property of C₁₄H₁₁ClN₂O

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₄H₁₁ClN₂O

There total 1 articles about C₁₄H₁₁ClN₂O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-3-chloropyridine (39620-04-7) + 2-bromo-3'-methoxyacetophenone (5000-65-7) → C14H11ClN2O (481049-37-0)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; Heating;

DOI:10.1016/j.bmcl.2007.02.079

Reference yield:

C14H11ClN2O (481049-37-0) → C27H30N6O (481048-80-0)

Guidance literature:

Multi-step reaction with 6 steps

1: POCl₃ / 20 °C

2: tetrahydrofuran / -78 - 0 °C

3: MnO₂ / CH₂Cl₂

4: K₂CO₃ / ethanol / 80 °C

5: rac-BINAP; Cs₂CO₃ / Pd(OAc)2 / 100 °C

6: BBr₃ / CH₂Cl₂ / -78 - 20 °C

With manganese(IV) oxide; boron tribromide; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; 1: Vilsmeier-Haack reaction / 5: Buchwald coupling;

DOI:10.1016/j.bmcl.2007.02.079

Reference yield:

C14H11ClN2O (481049-37-0) → C30H34N6O

Guidance literature:

Multi-step reaction with 7 steps

1: POCl₃ / 20 °C

2: tetrahydrofuran / -78 - 0 °C

3: MnO₂ / CH₂Cl₂

4: K₂CO₃ / ethanol / 80 °C

5: rac-BINAP; Cs₂CO₃ / Pd(OAc)2 / 100 °C

6: BBr₃ / CH₂Cl₂ / -78 - 20 °C

7: Cs₂CO₃ / dimethylformamide / 80 °C

With manganese(IV) oxide; boron tribromide; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trichlorophosphate; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; N,N-dimethyl-formamide; 1: Vilsmeier-Haack reaction / 5: Buchwald coupling;

DOI:10.1016/j.bmcl.2007.02.079

upstream raw materials:

2-amino-3-chloropyridine

2-bromo-3'-methoxyacetophenone

Downstream raw materials:

C₁₅H₁₁ClN₂O₂

C₁₇H₁₃ClN₂O₂

C₁₇H₁₁ClN₂O₂

C₂₃H₂₂ClN₅O