3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Base Information

• Chemical Name: 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester
• CAS No.: 132975-00-9
• Molecular Formula: C₂₄H₂₁N₅O₉S₄
• Molecular Weight: 651.723

Synonyms:

Chemical Property of 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

There total 3 articles about 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

p-nitrobenzyl 7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate (80756-45-2) → 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (132975-00-9) + 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,5,8-trioxo-7-(2-thiophen-2-yl-acetylamino)-5λ6-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (132975-01-0)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 25 ℃; for 6h;

Reference yield:

7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>ceph-3-em-4-carboxylic acid (26970-95-6) → 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (132975-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / sodium bicarbonate / dimethylformamide / 6 h / Ambient temperature

2: 37 percent / m-CPBA / CH₂Cl₂ / 6 h / 25 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

1-bromomethyl-4-nitro-benzene (100-11-8) → 3-(5-Methyl-[1,3,4]thiadiazole-2-sulfonylmethyl)-5,8-dioxo-7-(2-thiophen-2-yl-acetylamino)-5λ4-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (132975-00-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 50 percent / sodium bicarbonate / dimethylformamide / 6 h / Ambient temperature

2: 37 percent / m-CPBA / CH₂Cl₂ / 6 h / 25 °C

With sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

p-nitrobenzyl 7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>ceph-3-em-4-carboxylate

7β-(thiophen-2-acetamido)-3-<(2-methyl-1,3,4-thiadiazol-5-yl)thiomethyl>ceph-3-em-4-carboxylic acid

1-bromomethyl-4-nitro-benzene

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