Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester

Base Information

• Chemical Name: Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester
• CAS No.: 224302-82-3
• Molecular Formula: C₄₅H₄₂N₆O₇
• Molecular Weight: 778.864
• Mol file: 224302-82-3.mol

Synonyms:

Chemical Property of Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester

There total 6 articles about Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diphenylcarbamic chloride (83-01-2) → Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester (224302-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: (iPr)2NEt

2: TBAF / tetrahydrofuran

3: pyridine

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1: Condensation / 2: Desilylation / 3: Condensation;

DOI:10.1016/S0960-894X(00)00432-7

Reference yield:

9-((2R,3aS,9aR)-5,7-Diisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-2-methylamino-1,9-dihydro-purin-6-one → Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester (224302-82-3)

Guidance literature:

Multi-step reaction with 3 steps

1: (iPr)2NEt

2: TBAF / tetrahydrofuran

3: pyridine

With pyridine; tetrabutyl ammonium fluoride; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1: Condensation / 2: Desilylation / 3: Condensation;

DOI:10.1016/S0960-894X(00)00432-7

Reference yield:

2-Amino-9-((2R,3aS,9aR)-5,7-diisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1,9-dihydro-purin-6-one → Diphenyl-carbamic acid 9-{(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-2-methylamino-9H-purin-6-yl ester (224302-82-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 70 percent / AcOH

2: NaBH₄ / dimethylsulfoxide

3: (iPr)2NEt

4: TBAF / tetrahydrofuran

5: pyridine

With pyridine; sodium tetrahydroborate; tetrabutyl ammonium fluoride; acetic acid; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dimethyl sulfoxide; 1: Oxidation / 2: Reduction / 3: Condensation / 4: Desilylation / 5: Condensation;

DOI:10.1016/S0960-894X(00)00432-7

upstream raw materials:

4,4'-dimethoxytrityl chloride

Diphenyl-carbamic acid 9-((2R,4S,5R)-4-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-2-methylamino-9H-purin-6-yl ester

diphenylcarbamic chloride