benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

Base Information

Chemical Name:benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate
CAS No.:343626-02-8
Molecular Formula:C₅₆H₆₇N₇O₁₁
Molecular Weight:1014.19
Hs Code.:

benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

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Chemical Property of benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

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Technology Process of benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

There total 7 articles about benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 181483-85-2
7-azidoheptanamide

: 343626-02-8
benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: molecular sieves / CH₂Cl₂ / 24 h / Heating

2: SOCl₂ / CH₂Cl₂ / 2 h / Heating

3: 13.4 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

4: 1N NaOH / 1,2-dimethoxy-ethane / 1.5 h / 20 °C

5: 17.5 g / DCC; HOBT / CH₂Cl₂ / 20 h / 20 °C

6: Ph₃P / H₂O; tetrahydrofuran / Heating

7: 17.5 g / tetrahydrofuran / 6 h / 20 °C

With sodium hydroxide; thionyl chloride; molecular sieve; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00130-2

Reference yield:

: (7-azido-heptanoylamino)-chloro-acetic acid methyl ester

: 343626-02-8
benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

Guidance literature:: Multi-step reaction with 5 steps

1: 13.4 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

2: 1N NaOH / 1,2-dimethoxy-ethane / 1.5 h / 20 °C

3: 17.5 g / DCC; HOBT / CH₂Cl₂ / 20 h / 20 °C

4: Ph₃P / H₂O; tetrahydrofuran / Heating

5: 17.5 g / tetrahydrofuran / 6 h / 20 °C

With sodium hydroxide; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00130-2

Reference yield:

: acetic acid, <(7-azido-1-oxoheptyl)amino>hydroxy-, methyl ester

: 343626-02-8
benzyl 21-[(benzyloxy)carbonyl]amino-11-(benzyloxy)-4-[(benzyloxy)carbonyl]-10,13,23-trioxo-25-phenyl-24-oxa-4,9,12,20,22-pentaazapentacos-21-en-1-yl carbamate

Guidance literature:: Multi-step reaction with 6 steps

1: SOCl₂ / CH₂Cl₂ / 2 h / Heating

2: 13.4 g / Et₃N / CH₂Cl₂ / 24 h / 20 °C

3: 1N NaOH / 1,2-dimethoxy-ethane / 1.5 h / 20 °C

4: 17.5 g / DCC; HOBT / CH₂Cl₂ / 20 h / 20 °C

5: Ph₃P / H₂O; tetrahydrofuran / Heating

6: 17.5 g / tetrahydrofuran / 6 h / 20 °C

With sodium hydroxide; thionyl chloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; triphenylphosphine; In tetrahydrofuran; 1,2-dimethoxyethane; dichloromethane; water;
DOI:10.1016/S0040-4020(01)00130-2