4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan

Base Information

Chemical Name:4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan
CAS No.:89178-26-7
Molecular Formula:C₂₈H₃₃NO₃
Molecular Weight:431.575
Hs Code.:

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan

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Technology Process of 4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan

There total 2 articles about 4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 89178-22-3
7-<(n-butylthio)methylene>hydrocodone

: 89178-26-7,89196-37-2
4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaBH₄, 1 N aq. NaOH, 2.) 10percent aq. H₂SO₄ / 1.) MeOH, 2 h, 2.) MeOH, reflux, 2 h

2: diethyl ether / 1 h

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; In diethyl ether;
DOI:10.1021/jm00371a013

Reference yield:

: 125-29-1
Hydrocodone

: 89178-26-7,89196-37-2
4,5α-epoxy-7-(1-hydroxy-4-phenylbutyl)-3-methoxy-17-methyl-6,7-didehydromorphinan

Guidance literature:: Multi-step reaction with 4 steps

1: 84 percent / toluene / 16 h / Heating

2: 90 percent / p-toluenesulfonic acid hydrate / benzene / 20 h / Heating

3: 1.) NaBH₄, 1 N aq. NaOH, 2.) 10percent aq. H₂SO₄ / 1.) MeOH, 2 h, 2.) MeOH, reflux, 2 h

4: diethyl ether / 1 h

With sodium hydroxide; sodium tetrahydroborate; sulfuric acid; toluene-4-sulfonic acid; In diethyl ether; toluene; benzene;
DOI:10.1021/jm00371a013