Technology Process of (2S,3R)-3-(3-carboxy-5-(2-oxo-1,2-dihydropyrimidin-5-yl)phenyl)pyrrolidin-2-carboxylic acid hydrochloride
There total 8 articles about (2S,3R)-3-(3-carboxy-5-(2-oxo-1,2-dihydropyrimidin-5-yl)phenyl)pyrrolidin-2-carboxylic acid hydrochloride which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C21H23N3O7;
With
boron tribromide;
In
dichloromethane;
at 20 ℃;
for 2h;
With
hydrogenchloride;
In
water;
DOI:10.1021/acschemneuro.0c00003
- Guidance literature:
-
Multi-step reaction with 10 steps
1: sulfuric acid / 20 h / Reflux
2: diethyl ether / 1.5 h / 20 °C
3: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C
4: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C
5: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
6: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux
7: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C
8: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere; Sealed tube
9: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 2 h / 0 °C
10: boron tribromide / dichloromethane / 2 h / 20 °C
With
1H-imidazole; dmap; sodium periodate; lithium aluminium tetrahydride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrakis(triphenylphosphine) palladium(0); boron trichloride methyl sulfide complex; ruthenium(III) trichloride hydrate; sulfuric acid; tetrabutyl ammonium fluoride; water; boron tribromide; sodium carbonate; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; diethyl ether; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
8: |Suzuki Coupling;
DOI:10.1021/acschemneuro.0c00003
- Guidance literature:
-
Multi-step reaction with 8 steps
1: lithium aluminium tetrahydride / tetrahydrofuran / 14 h / 0 - 20 °C
2: 1H-imidazole; dmap / N,N-dimethyl-formamide / 21 h / 20 °C
3: chloro(1,5-cyclooctadiene)rhodium(I) dimer; caesium carbonate; water / tetrahydrofuran / 24 h / 20 °C / Inert atmosphere
4: boron trichloride methyl sulfide complex / tetrahydrofuran / 2 h / Reflux
5: tetrabutyl ammonium fluoride / tetrahydrofuran / 7 h / 20 °C
6: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / 1,4-dioxane / 4 h / 95 °C / Inert atmosphere; Sealed tube
7: sodium periodate; ruthenium(III) trichloride hydrate / ethyl acetate; acetonitrile; water / 2 h / 0 °C
8: boron tribromide / dichloromethane / 2 h / 20 °C
With
1H-imidazole; dmap; sodium periodate; lithium aluminium tetrahydride; chloro(1,5-cyclooctadiene)rhodium(I) dimer; tetrakis(triphenylphosphine) palladium(0); boron trichloride methyl sulfide complex; ruthenium(III) trichloride hydrate; tetrabutyl ammonium fluoride; water; boron tribromide; sodium carbonate; caesium carbonate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
6: |Suzuki Coupling;
DOI:10.1021/acschemneuro.0c00003
