Benzene, 1,4-bis(2-bromoethyl)-2,3,5,6-tetramethyl-

Base Information

• Chemical Name: Benzene, 1,4-bis(2-bromoethyl)-2,3,5,6-tetramethyl-
• CAS No.: 105537-28-8
• Molecular Formula: C₁₄H₂₀Br₂
• Molecular Weight: 348.121
• Mol file: 105537-28-8.mol

Synonyms:

Chemical Property of Benzene, 1,4-bis(2-bromoethyl)-2,3,5,6-tetramethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1,4-bis(2-bromoethyl)-2,3,5,6-tetramethyl-

There total 4 articles about Benzene, 1,4-bis(2-bromoethyl)-2,3,5,6-tetramethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3,5,6-tetramethylphenylene-1,4-diacetonitrile (1675-71-4) → 1,4-Bis(2-bromoethyl)-2,3,5,6-tetramethylbenzene (105537-28-8)

Guidance literature:

Multi-step reaction with 4 steps

1: 88 percent / 50percent sulfuric acid / 9 h / Heating

2: 69 percent / conc. sulfuric acid / tetrahydrofuran / 16 h / Heating

3: 98 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

4: 88 percent / tetrabromomethane, triphenylphosphane / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; triphenylphosphine; In tetrahydrofuran; dichloromethane;

Reference yield:

1,4-bis(bromomethyl)-2,3,5,6-tetramethylbenzene (35168-64-0) → 1,4-Bis(2-bromoethyl)-2,3,5,6-tetramethylbenzene (105537-28-8)

Guidance literature:

Multi-step reaction with 5 steps

1: 94 percent / dimethylsulfoxide / 1.) 2 h, 50 deg C; 2.) short time, 85 deg C

2: 88 percent / 50percent sulfuric acid / 9 h / Heating

3: 69 percent / conc. sulfuric acid / tetrahydrofuran / 16 h / Heating

4: 98 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

5: 88 percent / tetrabromomethane, triphenylphosphane / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; triphenylphosphine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;

Reference yield:

2,3,5,6-Tetramethyl-1,4-benzenediacetic Acid (15657-67-7) → 1,4-Bis(2-bromoethyl)-2,3,5,6-tetramethylbenzene (105537-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / conc. sulfuric acid / tetrahydrofuran / 16 h / Heating

2: 98 percent / LiAlH₄ / tetrahydrofuran / 1 h / 20 °C

3: 88 percent / tetrabromomethane, triphenylphosphane / CH₂Cl₂ / 12 h / 20 °C

With lithium aluminium tetrahydride; carbon tetrabromide; sulfuric acid; triphenylphosphine; In tetrahydrofuran; dichloromethane;

upstream raw materials:

1,4-bis(bromomethyl)-2,3,5,6-tetramethylbenzene

2,3,5,6-tetramethylphenylene-1,4-diacetonitrile

2,3,5,6-Tetramethyl-1,4-benzenediacetic Acid

(4-Methoxycarbonylmethyl-2,3,5,6-tetramethyl-phenyl)-acetic acid methyl ester

Downstream raw materials:

1,4-Bis(2-mercaptoethyl)-2,3,5,6-tetramethylbenzene