Technology Process of 1(6H)-Pyridazinebutanoic acid, 3-cyclohexyl-6-imino-,
monohydrobromide
There total 7 articles about 1(6H)-Pyridazinebutanoic acid, 3-cyclohexyl-6-imino-,
monohydrobromide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen bromide;
In
acetic acid;
at 100 ℃;
for 10h;
DOI:10.1021/jm00385a003
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 30 percent / ethanol / a) RT, 1h, b) 60 deg C, 6 h7
2: 78 percent / hydrazine hydrate / butan-1-ol / a) RT, 1h, b) reflux, overnight
3: phosphorus oxychloride / 4 h / 85 - 95 °C
4: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
5: H2 / Raney Ni / methanol / 20 °C / 760 Torr
6: dimethylformamide / 8 h / 80 °C
7: 48percentHBr / acetic acid / 10 h / 100 °C
With
hydrogen bromide; hydrogen; hydrazine hydrate; trichlorophosphate;
nickel;
In
methanol; ethanol; acetic acid; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm00385a003
- Guidance literature:
-
Multi-step reaction with 4 steps
1: hydrazine hydrate / butan-1-ol / 6 h / 100 °C
2: H2 / Raney Ni / methanol / 20 °C / 760 Torr
3: dimethylformamide / 8 h / 80 °C
4: 48percentHBr / acetic acid / 10 h / 100 °C
With
hydrogen bromide; hydrogen; hydrazine hydrate;
nickel;
In
methanol; acetic acid; N,N-dimethyl-formamide; butan-1-ol;
DOI:10.1021/jm00385a003
