4-Methyl-4,5-dihydropyridazin-3(2H)-one

Base Information

• Chemical Name: 4-Methyl-4,5-dihydropyridazin-3(2H)-one
• CAS No.: 105537-87-9
• Molecular Formula: C5H8N2O
• Molecular Weight: 112.13
• Hs Code.: 2933990090
• Mol file: 105537-87-9.mol

Synonyms:4-Methyl-4,5-dihydro-2H-pyridazin-3-on;4-methyl-4,5-dihydropyridazin-3(2H)-one;4-methyl-4,5-dihydro-2H-pyridazin-3-one;

Chemical Property of 4-Methyl-4,5-dihydropyridazin-3(2H)-one

Chemical Property:

• PSA: 41.46000
• LogP: -0.10740

Purity/Quality:

99% ^*data from raw suppliers

4-Methyl-4,5-dihydropyridazin-3(2H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methyl-4,5-dihydropyridazin-3(2H)-one

There total 4 articles about 4-Methyl-4,5-dihydropyridazin-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-methyl-4-oxobutyric acid ethyl ester (39484-57-6) → 4-methyl-4,5-dihydro-3(2H)-pyridazinone (105537-87-9)

Guidance literature:

With hydrazine; In ethanol; for 22h; Heating / reflux;

Reference yield:

α-methyl-γ-hydroxybutyrolactone (61892-47-5) → 4-methyl-4,5-dihydro-3(2H)-pyridazinone (105537-87-9)

Guidance literature:

With hydrazine hydrate; In ethanol; for 4h; Heating;

DOI:10.1021/jm00385a003

Reference yield:

ethyl 2-methyl-4,4-diethoxybutanoate (105537-47-1) → 4-methyl-4,5-dihydro-3(2H)-pyridazinone (105537-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: NaOH, H₂O / ethanol / 50 °C

2: hydrazine hydrate / ethanol / 4 h / Heating

With sodium hydroxide; water; hydrazine hydrate; In ethanol;

DOI:10.1021/jm00385a003

upstream raw materials:

2-methyl-4-oxobutyric acid ethyl ester

α-methyl-γ-hydroxybutyrolactone

hydrazine hydrate

ethyl 2-methyl-4,4-diethoxybutanoate

Downstream raw materials:

4-methylpyridazin-3(2H)-one

3-chloro-4-methylpyridazine

3-amino-4-methylpyridazine

1-(4-methylpyridazin-3-yl)hydrazine