1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

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Chemical Name:1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea
CAS No.:1256601-50-9
Molecular Formula:C₂₅H₃₃F₆N₇S
Molecular Weight:577.64
Hs Code.:

1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

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Chemical Property of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

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Technology Process of 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

There total 9 articles about 1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₇H₃₂F₉N₇OS

: 1256601-50-9
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

Guidance literature:: With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; Inert atmosphere;
DOI:10.3390/molecules15118327

Reference yield:

: C₁₄H₁₆F₃NO₄S

: 1256601-50-9
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium azide; sodium iodide / 1,4-dioxane; dimethyl sulfoxide / 80 °C / Inert atmosphere

2.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

3.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: tetrahydrofuran / 20 °C / Inert atmosphere

5.1: water; lithium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere

With sodium azide; chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; water; trifluoroacetic acid; sodium iodide; lithium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; dimethyl sulfoxide; 2.1: Huisgen reaction;
DOI:10.3390/molecules15118327

Reference yield:

: 1229407-43-5
(R)-1-(2-(azidomethyl)-1-pyrrolidinyl)-2,2,2-trifluoroethanone

: 1256601-50-9
1-(3,5-bis(trifluoromethyl)phenyl)-3-((1R,2R)-2-(methyl(2-(1-((R)-pyrrolidin-2-ylmethyl)-1H-1,2,3-triazol-5-yl)ethyl)amino)cyclohexyl)thiourea

Guidance literature:: Multi-step reaction with 4 steps

1.1: chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer / tetrahydrofuran / 8 h / Inert atmosphere; Reflux

2.1: trifluoroacetic acid / dichloromethane / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: tetrahydrofuran / 20 °C / Inert atmosphere

4.1: water; lithium hydroxide / tetrahydrofuran / 20 °C / Inert atmosphere

With chloro(pentamethylcyclopentadienyl)ruthenium(II) tetramer; water; trifluoroacetic acid; lithium hydroxide; In tetrahydrofuran; dichloromethane; 1.1: Huisgen reaction;
DOI:10.3390/molecules15118327