(S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

Base Information

• Chemical Name: (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid
• CAS No.: 140212-85-7
• Molecular Formula: C₂HF₃O₂*C₃₅H₄₁F₅N₈O₇S₂
• Molecular Weight: 958.908
• Mol file: 140212-85-7.mol

Synonyms:

Chemical Property of (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid

There total 3 articles about (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Boc-L-Leu-L-(gln)Thz-(gly)Thz-L-Val-L-Pro-OH (140387-18-4) → (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (140212-85-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / N,N'-Dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane; dimethylformamide / 1) -20 deg C, 2) 12h, RT

2: 0.5 h / Ambient temperature

With dicyclohexyl-carbodiimide; In 1,2-dimethoxyethane; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)85446-6

Reference yield:

N-t-Boc-L-Leu-L-(Gln)Thz-(Gly)Thz-L-Val-L-Pro-OMe (111238-38-1) → (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (140212-85-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / 1N NaOH / dioxane; H₂O / 3 h / Ambient temperature

2: 87 percent / N,N'-Dicyclohexylcarbodiimide / 1,2-dimethoxy-ethane; dimethylformamide / 1) -20 deg C, 2) 12h, RT

3: 0.5 h / Ambient temperature

With sodium hydroxide; dicyclohexyl-carbodiimide; In 1,4-dioxane; 1,2-dimethoxyethane; water; N,N-dimethyl-formamide;

DOI:10.1016/S0040-4020(01)85446-6

Reference yield:

(S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester (128044-37-1) + trifluoroacetic acid (76-05-1) → (S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-Amino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester; compound with trifluoro-acetic acid (140212-85-7)

Guidance literature:

for 0.5h; Ambient temperature;

DOI:10.1016/S0040-4020(01)85446-6

upstream raw materials:

(S)-1-[(S)-2-({2-[({2-[(S)-1-((S)-2-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-3-carbamoyl-propyl]-thiazole-4-carbonyl}-amino)-methyl]-thiazole-4-carbonyl}-amino)-3-methyl-butyryl]-pyrrolidine-2-carboxylic acid pentafluorophenyl ester

trifluoroacetic acid

Boc-L-Leu-L-(gln)Thz-(gly)Thz-L-Val-L-Pro-OH

N-t-Boc-L-Leu-L-(Gln)Thz-(Gly)Thz-L-Val-L-Pro-OMe