C₂₃H₂₅N₅O₃S

Base Information

• Chemical Name: C₂₃H₂₅N₅O₃S
• CAS No.: 1351811-79-4
• Molecular Formula: C₂₃H₂₅N₅O₃S
• Molecular Weight: 451.549
• Mol file: 1351811-79-4.mol

Synonyms:

Chemical Property of C₂₃H₂₅N₅O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₃H₂₅N₅O₃S

There total 10 articles about C₂₃H₂₅N₅O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C28H33N5O5S → C23H25N5O3S (1351811-79-4)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; Reflux;

DOI:10.1021/jm4000215

Reference yield:

3-bromo-4-fluoro-6-methylnitrobenzene (224185-19-7) → C23H25N5O3S (1351811-79-4)

Guidance literature:

Multi-step reaction with 8 steps

1: potassium hydroxide / acetonitrile / 22 h / 0 - 20 °C

2: sodium dithionite; ethanol / water / 5 h / 100 °C

3: acetic acid; sodium nitrite / water / 20 °C

4: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

5: triethylamine / acetonitrile / 0.83 h / 20 °C

6: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

7: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / tetrahydrofuran; water / 5 h / Reflux

8: trifluoroacetic acid / dichloromethane / 20 °C / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; sodium dithionite; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; ethanol; iodine; palladium diacetate; sodium carbonate; potassium carbonate; acetic acid; triethylamine; trifluoroacetic acid; potassium hydroxide; sodium nitrite; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling / 6: |Suzuki Coupling / 7: |Suzuki Coupling / 8: |Suzuki Coupling;

DOI:10.1021/jm4000215

Reference yield:

6-bromo-5-(cyclohexyloxy)-1H-indazole (1351812-82-2) → C23H25N5O3S (1351811-79-4)

Guidance literature:

Multi-step reaction with 5 steps

1: iodine; potassium hydroxide / N,N-dimethyl-formamide / 4 h / 20 °C

2: triethylamine / acetonitrile / 0.83 h / 20 °C

3: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium carbonate / tetrahydrofuran / 6 h / Inert atmosphere; Reflux

4: dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; palladium diacetate; potassium carbonate / tetrahydrofuran; water / 5 h / Reflux

5: trifluoroacetic acid / dichloromethane / 20 °C / Reflux

With dicyclohexyl-(2',6'-dimethoxybiphenyl-2-yl)-phosphane; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; iodine; palladium diacetate; sodium carbonate; potassium carbonate; triethylamine; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile; 3: |Suzuki Coupling / 4: |Suzuki Coupling / 5: |Suzuki Coupling;

DOI:10.1021/jm4000215

upstream raw materials:

3-bromo-4-fluoro-6-methylnitrobenzene

5-bromo-4-(cyclohexyloxy)-2-methylaniline

6-bromo-5-(cyclohexyloxy)-1H-indazole

tert-butyl 6-bromo-5-(cyclohexyloxy)-3-iodo-1H-indazole-1-carboxylate