7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one

Base Information

Chemical Name:7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one
CAS No.:105544-39-6
Molecular Formula:C7H5ClN2O2
Molecular Weight:184.58000
Hs Code.:2934999090
European Community (EC) Number:870-243-2
Mol file:105544-39-6.mol

Synonyms:105544-39-6;7-CHLORO-2H-PYRIDO[2,3-B]-1,4-OXAZIN-3(4H)-ONE;6-Chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one;6-chloro-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one;SCHEMBL18619838;MFCD00209963;AKOS006272190;AT11681;EN300-869832;6-chloro-1H,2H,3H-pyrido[2,3-b][1,4]oxazin-2-one

Suppliers and Price of 7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chemcia Scientific
6-Chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one ＞95%
1 G
$ 495.00

Chemcia Scientific
6-Chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one ＞95%
0.25 G
$ 230.00

Total 6 raw suppliers

Chemical Property of 7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one

Chemical Property:

Melting Point:212 °C(Solv: ethanol (64-17-5))
Boiling Point:413.9±45.0 °C(Predicted)
PKA:10.48±0.20(Predicted)
PSA：51.22000
Density:1.476±0.06 g/cm3(Predicted)
LogP:1.20390
XLogP3:1.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:0
Exact Mass:184.0039551
Heavy Atom Count:12
Complexity:200

Purity/Quality:

97% ^*data from raw suppliers

6-Chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one ＞95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(=O)NC2=C(O1)N=C(C=C2)Cl

Technology Process of 7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one

There total 4 articles about 7-Chloro-2H-pyrido[2,3-B]-1,4-oxazin-3(4H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 353293-30-8
methyl 2-[(3-amino-6-chloro-2-pyridyl)oxy]acetate

: 105544-39-6
6-chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one

Guidance literature:: With acetic acid; In ethanol; for 12h; Reflux;

Reference yield: 48.8%

: 91678-24-9
ethyl 2-((6-chloro-3-nitro-2-pyridyl)oxy)acetate

: 105544-39-6
6-chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one

Guidance literature:: With hydrogenchloride; tin; at 80 - 85 ℃; for 1h;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 105544-39-6
6-chloro-1H-pyrido[2,3-b][1,4]oxazin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / 1,4-dioxane; mineral oil / 0.25 h / 0 °C

1.2: 12 h

2.1: iron; ammonium chloride / water; tetrahydrofuran; methanol / 3 h / 10 - 35 °C / Reflux

3.1: acetic acid / ethanol / 12 h / Reflux

With iron; sodium hydride; ammonium chloride; acetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; water; mineral oil;