dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

Base Information

Chemical Name:dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate
CAS No.:925463-34-9
Molecular Formula:C₃₂H₃₄NO₅PS
Molecular Weight:575.665
Hs Code.:

Synonyms:

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Chemical Property of dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

Chemical Property:

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Technology Process of dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

There total 3 articles about dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 873586-57-3
(S)-p-bromobenzenesulfinamide

: 925463-34-9
dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) ethoxide / CH₂Cl₂ / 3 h / Heating

2.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

2.2: 54 percent / tetrahydrofuran / 3 h / -78 °C

3.1: 97 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

4.1: 44 percent / K₃PO₄ / Pd(PPh₃)4 / toluene / 18 h / Heating

With titanium(IV) tetraethanolate; potassium phosphate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 4.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.047

Reference yield:

: (S)-N-(2-methylpropylidene)-p-bromobenzenesulfinamide

: 925463-34-9
dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium bis(trimethylsilyl)amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 54 percent / tetrahydrofuran / 3 h / -78 °C

2.1: 97 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

3.1: 44 percent / K₃PO₄ / Pd(PPh₃)4 / toluene / 18 h / Heating

With potassium phosphate; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; toluene; 3.1: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.047

Reference yield:

: 925463-06-5
dibenzyl (S_S,R)-N-(p-bromobenzenesulfinyl)-2-amino-2-methylpropylphosphonate

: 925463-34-9
dibenzyl (R)-2-methyl-1-[({4-[(E)-2-phenylvinyl]phenyl}sulfonyl)amino]propylphosphonate

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 0.5 h / 0 °C

2: 44 percent / K₃PO₄ / Pd(PPh₃)4 / toluene / 18 h / Heating

With potassium phosphate; 3-chloro-benzenecarboperoxoic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In dichloromethane; toluene; 2: Suzuki coupling;
DOI:10.1016/j.bmc.2006.10.047