(3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride

Base Information

• Chemical Name: (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride
• CAS No.: 1404105-89-0
• Molecular Formula: C₂₂H₂₁N₂O₃S*Cl
• Molecular Weight: 428.939
• Mol file: 1404105-89-0.mol

Synonyms:

Chemical Property of (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride

There total 2 articles about (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3R)-7-chloromethyl-8-cyclopropyl-5-oxo-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester (1404105-79-8) → (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride (1404105-89-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N,N-dimethyl-formamide; acetonitrile / 0.17 h / 0 - 20 °C / Inert atmosphere

1.2: 4 h / 75 °C / Inert atmosphere

2.1: acetic acid / methanol; acetonitrile / 0.17 h / 80 °C / Inert atmosphere; Microwave irradiation

With acetic acid; In methanol; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2012.08.100

Reference yield:

methyl 2-(cyclopropylmethyl)Δ2-1 ,3-thiazoline-4-carboxylate → (3R)-10-cyclopropyl-2,3-dihydro-7-methyl-3-methoxycarbonyl-5-oxo-8-phenylthiazolo[3,2-b][2,7]naphthyridinium chloride (1404105-89-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: trifluoroacetic acid / dichloromethane / 0.05 h / 120 °C / Inert atmosphere; Microwave irradiation

2.1: N,N-dimethyl-formamide; acetonitrile / 0.17 h / 0 - 20 °C / Inert atmosphere

2.2: 4 h / 75 °C / Inert atmosphere

3.1: acetic acid / methanol; acetonitrile / 0.17 h / 80 °C / Inert atmosphere; Microwave irradiation

With acetic acid; trifluoroacetic acid; In methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.tetlet.2012.08.100

upstream raw materials:

(3R)-7-chloromethyl-8-cyclopropyl-5-oxo-2,3-dihydrothiazolo[3,2-a]pyridine-3-carboxylic acid methyl ester