Technology Process of (R)-(-)-4,4-dimethyl-3-phenylpentan-2-one
There total 12 articles about (R)-(-)-4,4-dimethyl-3-phenylpentan-2-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 0.086 g / phosphorus tricloride, pyridine / 1.5 h / 50 °C
2: 2.55 g / SnCl4 / CH2Cl2 / 2 h / 0 °C
3: 0.381 g / 42 percent aq. H2SO4 / 96 h / Heating
4: 4.144 g / 47 percent HBr / 20 h / Heating
5: 2.835 g / diethyl ether / 3 h / Heating
6: 0.687 g / LiAlH4 / diethyl ether / 1.17 h / Heating
7: 1.015 g / NaH / tetrahydrofuran / 17.5 h / Ambient temperature
8: 0.351 g / Na / liquid ammonia / 1 h / Heating
9: 0.269 g / chromium trioxide, pyridine / CH2Cl2 / 0.67 h / Ambient temperature
With
pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; sodium; tin(IV) chloride; sodium hydride; phosphorus trichloride;
In
tetrahydrofuran; diethyl ether; dichloromethane; ammonia;
DOI:10.1039/P29880001875
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 0.495 g / thionyl chloride / CCl4 / 1.17 h / -53 - -22 °C
2: 2.55 g / SnCl4 / CH2Cl2 / 2 h / 0 °C
3: 0.381 g / 42 percent aq. H2SO4 / 96 h / Heating
4: 4.144 g / 47 percent HBr / 20 h / Heating
5: 2.835 g / diethyl ether / 3 h / Heating
6: 0.687 g / LiAlH4 / diethyl ether / 1.17 h / Heating
7: 1.015 g / NaH / tetrahydrofuran / 17.5 h / Ambient temperature
8: 0.351 g / Na / liquid ammonia / 1 h / Heating
9: 0.269 g / chromium trioxide, pyridine / CH2Cl2 / 0.67 h / Ambient temperature
With
pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; thionyl chloride; sulfuric acid; hydrogen bromide; sodium; tin(IV) chloride; sodium hydride;
In
tetrahydrofuran; tetrachloromethane; diethyl ether; dichloromethane; ammonia;
DOI:10.1039/P29880001875
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 2.55 g / SnCl4 / CH2Cl2 / 2 h / 0 °C
2: 0.381 g / 42 percent aq. H2SO4 / 96 h / Heating
3: 4.144 g / 47 percent HBr / 20 h / Heating
4: 2.835 g / diethyl ether / 3 h / Heating
5: 0.687 g / LiAlH4 / diethyl ether / 1.17 h / Heating
6: 1.015 g / NaH / tetrahydrofuran / 17.5 h / Ambient temperature
7: 0.351 g / Na / liquid ammonia / 1 h / Heating
8: 0.269 g / chromium trioxide, pyridine / CH2Cl2 / 0.67 h / Ambient temperature
With
pyridine; chromium(VI) oxide; lithium aluminium tetrahydride; sulfuric acid; hydrogen bromide; sodium; tin(IV) chloride; sodium hydride;
In
tetrahydrofuran; diethyl ether; dichloromethane; ammonia;
DOI:10.1039/P29880001875