(1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester

Base Information

• Chemical Name: (1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester
• CAS No.: 141395-37-1
• Molecular Formula: C₁₉H₂₀F₆O₅
• Molecular Weight: 442.355
• Mol file: 141395-37-1.mol

Synonyms:

Chemical Property of (1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester

There total 1 articles about (1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol (141329-76-2) + 1,2-cis-cyclohexanedicarboxylic anhydride (13149-00-3) → (1R,2S)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester (141329-77-3) + (1S,2R)-Cyclohexane-1,2-dicarboxylic acid mono-((S)-4,4,4-trifluoro-3-hydroxy-1-phenyl-3-trifluoromethyl-butyl) ester (141395-37-1)

Guidance literature:

With sodium hydride; In toluene; at -78 ℃; for 1h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1246/cl.1992.389

upstream raw materials:

(S)-1-phenyl-3,3-bis(trifluoromethyl)propan-1,3-diol

1,2-cis-cyclohexanedicarboxylic anhydride