10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Base Information

Chemical Name:10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester
CAS No.:1360559-32-5
Molecular Formula:C₄₃H₇₁N₉O₇
Molecular Weight:826.093
Hs Code.:

10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

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Chemical Property of 10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

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Technology Process of 10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

There total 3 articles about 10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 848761-24-0
10-[3-(3-amino-propionylamino)-propyl]-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

: 1360559-32-5
10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate / N,N-dimethyl-formamide / 20 °C

2: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 80 °C

With caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.008

Reference yield:

: 10-[3-(3-benzyloxycarbonylamino-propionylamino)-propyl]-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

: 1360559-32-5
10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 760.05 Torr

2: caesium carbonate / N,N-dimethyl-formamide / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 80 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2012.01.008

Reference yield:

: 473895-01-1
10-(3-amino-propyl)-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

: 1360559-32-5
10-{3-[3-(3-cyclohexylamino-quinoxalin-2-ylamino)-propionylamino]-propyl}-1,4,7,10-tetraaza-cyclododecane-1,4,7-tricarboxylic acid tri-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / acetonitrile / 1 h

2: palladium 10% on activated carbon; hydrogen / ethyl acetate / 24 h / 760.05 Torr

3: caesium carbonate / N,N-dimethyl-formamide / 20 °C

4: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h / 80 °C

With palladium 10% on activated carbon; hydrogen; caesium carbonate; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.01.008