Technology Process of 2-amino-9-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>-6-chloropurine
There total 5 articles about 2-amino-9-<1,4-bis<(4-methoxybenzyl)oxy>but-2-oxy>-6-chloropurine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) (CF3CO2)2Hg, H2O, 2.) aq. NaOH, NaBH4 / 1.) THF, RT, 15 min
2: 63 percent / Ph3P, diethyl azodicarboxylate (DEAD) / tetrahydrofuran / 24 h / 20 °C
3: 68 percent / methylhydrazine / CH2Cl2 / 0.67 h / Ambient temperature
4: 62 percent / Et3N / dioxane / 1.5 h / 100 °C
5: 1.) diethoxymethyl acetate, 2.) aq. NH3 / 1.) 120 deg C, 1 h, 2.) MeOH, a.) 50 deg C, 1 h, b.) RT, 4 h
With
ammonium hydroxide; sodium hydroxide; sodium tetrahydroborate; diethoxymethyl acetate; water; mercury(II) trifluoroacetate; triethylamine; triphenylphosphine; methylhydrazine; diethylazodicarboxylate;
In
tetrahydrofuran; 1,4-dioxane; dichloromethane;
DOI:10.1021/jm00105a010
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 62 percent / Et3N / dioxane / 1.5 h / 100 °C
2: 1.) diethoxymethyl acetate, 2.) aq. NH3 / 1.) 120 deg C, 1 h, 2.) MeOH, a.) 50 deg C, 1 h, b.) RT, 4 h
With
ammonium hydroxide; diethoxymethyl acetate; triethylamine;
In
1,4-dioxane;
DOI:10.1021/jm00105a010
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / methylhydrazine / CH2Cl2 / 0.67 h / Ambient temperature
2: 62 percent / Et3N / dioxane / 1.5 h / 100 °C
3: 1.) diethoxymethyl acetate, 2.) aq. NH3 / 1.) 120 deg C, 1 h, 2.) MeOH, a.) 50 deg C, 1 h, b.) RT, 4 h
With
ammonium hydroxide; diethoxymethyl acetate; triethylamine; methylhydrazine;
In
1,4-dioxane; dichloromethane;
DOI:10.1021/jm00105a010
