4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Base Information

• Chemical Name: 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole
• CAS No.: 1926172-50-0
• Molecular Formula: C₁₃H₁₅BrN₂O
• Molecular Weight: 295.179
• Mol file: 1926172-50-0.mol

Synonyms:

Chemical Property of 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

Chemical Property:

• Boiling Point: 419.1±45.0 °C(Predicted)
• PKA: -0.01±0.30(Predicted)
• Density: 1.55±0.1 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

96% purity ^*data from raw suppliers

4-Bromo-5-methyl-1-(tetrahydro-pyran-2-yl)-1H-indazole 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole

There total 1 articles about 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.3%

3,4-dihydro-2H-pyran (110-87-2) + 4-bromo-5-methyl-1H-indazole (926922-40-9) → 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1926172-50-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; at 15 ℃; for 2h;

Reference yield: 95.0%

Triisopropyl borate (5419-55-6) + 4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1926172-50-0) → (5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)boronic acid (2022976-34-5)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; at -78 - -65 ℃; for 3.5h;

Reference yield: 84.0%

4-bromo-5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole (1926172-50-0) + 3-ethyl-4-(1-(2-isopropylphenyl)-2-oxo-1,2,5,6,7,8-hexahydropyrido[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester → 3-ethyl-4-(1-(2-isopropylphenyl)-7-(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)-2-oxo-1,2,5,6,7,8-hexahydropyrido[3,4-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

Guidance literature:

With methanesulfonato(2-dicyclohexylphosphino-2’,6’-di-i-propoxy-1,1’-biphenyl)(2’-methylamino-1,1‘-biphenyl-2-yl)palladium(II); caesium carbonate; ruphos; In 1,4-dioxane; at 110 ℃; for 1.5h; Inert atmosphere; Microwave irradiation;

upstream raw materials:

3,4-dihydro-2H-pyran

4-bromo-5-methyl-1H-indazole

Downstream raw materials:

(5-methyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indazol-4-yl)boronic acid

Refernces

• 1、 -. "Pyrimidine derivative and application thereof in medicines". Paragraph 0651-0656. . Retrieved 2021/07/21.
• 2、 -. "HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF". Paragraph 0214. . Retrieved 2021/12/28.