N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

Base Information

Chemical Name:N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide
CAS No.:1624604-60-9
Molecular Formula:C₂₂H₁₈F₆N₄O₃
Molecular Weight:500.4
Hs Code.:

N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

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Chemical Property of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

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Technology Process of N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

There total 3 articles about N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1383985-09-8
5-(but-2-yn-1-yloxy)pyridine-2-carboxylic acid

: 1624604-60-9
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

Guidance literature:

Reference yield:

: 30766-12-2
methyl 5-hydroxypicolinate

: 1624604-60-9
N-(3-((4S,6S)-2-amino-4-(fluoromethyl)-6-(trifluoromethyl)-5,6-dihydro-4H-1,3-oxazin-4-yl)-4,5-difluorophenyl)-5-(but-2-yn-1-yloxy)picolinamide

Guidance literature:: Multi-step reaction with 3 steps

1: di-isopropyl azodicarboxylate / tetrahydrofuran

With di-isopropyl azodicarboxylate; In tetrahydrofuran;