2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Base Information

• Chemical Name: 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide
• CAS No.: 1566584-27-7
• Molecular Formula: C₁₅H₁₆ClN₃O
• Molecular Weight: 289.765
• Mol file: 1566584-27-7.mol

Synonyms:

Chemical Property of 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide

There total 5 articles about 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)acetamide (1566584-26-6) → 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide (1566584-27-7)

Guidance literature:

With platinum(IV) oxide; hydrogen; In methanol; N,N-dimethyl-formamide; for 40h;

Reference yield:

2-(2-((trimethylsilyl)ethynyl)phenyl)acetamide → 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide (1566584-27-7)

Guidance literature:

Multi-step reaction with 3 steps

1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran; dichloromethane / 1 h / 5 °C

2: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.33 h / 70 °C / Inert atmosphere

3: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 40 h

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

o-iodophenylacetic acid (18698-96-9) → 2-(2-(2-(2-chloro-5-methylpyrimidin-4-yl)ethyl)phenyl)acetamide (1566584-27-7)

Guidance literature:

Multi-step reaction with 5 steps

1.1: thionyl chloride / 3 h / 75 °C

1.2: 20 h / 60 °C

2.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 3 h / 50 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran; dichloromethane / 1 h / 5 °C

4.1: copper(l) iodide; triethylamine; bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 0.33 h / 70 °C / Inert atmosphere

5.1: hydrogen; platinum(IV) oxide / N,N-dimethyl-formamide; methanol / 40 h

With platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; thionyl chloride; tetrabutyl ammonium fluoride; hydrogen; acetic acid; triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

o-iodophenylacetic acid

2-(2-ethynylphenyl)acetamide

2-(2-((2-chloro-5-methylpyrimidin-4-yl)ethynyl)phenyl)acetamide

2-(2-iodophenyl)-acetamide

Downstream raw materials:

tert-butyl 4-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)phenoxy)piperidine-1-carboxylate

2-(2-(2-(5-methyl-2-((4-(piperidin-4-yloxy)phenyl)amino)pyrimidin-4-yl)ethyl)phenyl)acetamide

methyl 1-(4-(4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-ylamino)phenyl)cyclobutylcarbamate

tert-butyl 3-(4-((4-(2-(2-amino-2-oxoethyl)phenethyl)-5-methylpyrimidin-2-yl)amino)-1H-pyrazole-1-yl)azetidine-1-carboxylate