C₁₈H₂₂ClF₂NO₂

Base Information

Chemical Name:C₁₈H₂₂ClF₂NO₂
CAS No.:1599478-20-2
Molecular Formula:C₁₈H₂₂ClF₂NO₂
Molecular Weight:357.828
Hs Code.:

C<sub>18</sub>H<sub>22</sub>ClF<sub>2</sub>NO<sub>2</sub>

Synonyms:

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Chemical Property of C₁₈H₂₂ClF₂NO₂

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Technology Process of C₁₈H₂₂ClF₂NO₂

There total 6 articles about C₁₈H₂₂ClF₂NO₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1346229-41-1
tert-butyl 9-(2-methoxy-2-oxoethyl)-3-azaspiro[5.5]undecane-3-carboxylate

: 1599478-20-2
C₁₈H₂₂ClF₂NO₂

Guidance literature:: Multi-step reaction with 3 steps

1: trifluoroacetic acid / dichloromethane / 24 h / 25 °C / Inert atmosphere

2: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / Inert atmosphere; Heating

3: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water;
DOI:10.1021/acsmedchemlett.6b00360

Reference yield:

: 1017623-70-9
methyl 2-(3-azaspiro[5.5]undecan-9-yl)acetate

: 1599478-20-2
C₁₈H₂₂ClF₂NO₂

Guidance literature:: Multi-step reaction with 2 steps

1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / Inert atmosphere; Heating

2: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; water;
DOI:10.1021/acsmedchemlett.6b00360

Reference yield:

: 138163-08-3
N-(benzyloxycarbonyl)piperidine-4-carboxaldehyde

: 1599478-20-2
C₁₈H₂₂ClF₂NO₂

Guidance literature:: Multi-step reaction with 6 steps

1.1: potassium hydroxide / ethanol; water / 1 h / 100 °C

2.1: sodium hydride / mineral oil; tetrahydrofuran / 1.5 h / 0 - 30 °C / Inert atmosphere

2.2: 40 - 50 °C / Inert atmosphere

3.1: hydrogen; palladium 10% on activated carbon / methanol / 24 h / 35 - 40 °C / 2585.81 Torr

4.1: trifluoroacetic acid / dichloromethane / 24 h / 25 °C / Inert atmosphere

5.1: caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 16 h / Inert atmosphere; Heating

6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; mineral oil; 2.1: |Horner-Wadsworth-Emmons Olefination / 2.2: |Horner-Wadsworth-Emmons Olefination;
DOI:10.1021/acsmedchemlett.6b00360