10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

Base Information

Chemical Name:10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester
CAS No.:79228-13-0
Molecular Formula:C₂₇H₂₉N₃O₅S
Molecular Weight:507.61
Hs Code.:

10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

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Chemical Property of 10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

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Technology Process of 10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

There total 6 articles about 10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79228-07-2
(2R,12bS)-3-Eth-(E)-ylidene-4-oxo-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine-2-carbaldehyde

: 79228-13-0
10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: BF₃*Et₂O / CH₂Cl₂ / 0 °C

2: i-Bu₂AlH / 1,2-dimethoxy-ethane / -55 °C

3: NaBH₃CN / tetrahydrofuran / from -70 up to room temp.

4: CH₃I, CaCO₃ / H₂O; acetone / Ambient temperature

5: H₂O; tetrahydrofuran

6: CH₂Cl₂; pyridine

With boron trifluoride diethyl etherate; diisobutylaluminium hydride; sodium cyanoborohydride; calcium carbonate; methyl iodide; In tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(01)90397-1

Reference yield:

: 79235-45-3
(2R,12bS)-2-[1,3]Dithiolan-2-yl-3-eth-(E)-ylidene-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizine

: 79228-13-0
10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: NaBH₃CN / tetrahydrofuran / from -70 up to room temp.

2: CH₃I, CaCO₃ / H₂O; acetone / Ambient temperature

3: H₂O; tetrahydrofuran

4: CH₂Cl₂; pyridine

With sodium cyanoborohydride; calcium carbonate; methyl iodide; In tetrahydrofuran; pyridine; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(01)90397-1

Reference yield:

: 79228-08-3
(2R,12bS)-2-[1,3]Dithiolan-2-yl-3-eth-(E)-ylidene-2,3,6,7,12,12b-hexahydro-1H-indolo[2,3-a]quinolizin-4-one

: 79228-13-0
10-(Cyano-methanesulfonyloxy-methyl)-9-eth-(E)-ylidene-5,6,8,9,10,11,12,13-octahydro-7,13-diaza-cyclodeca[a]indene-7-carboxylic acid phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: i-Bu₂AlH / 1,2-dimethoxy-ethane / -55 °C

2: NaBH₃CN / tetrahydrofuran / from -70 up to room temp.

3: CH₃I, CaCO₃ / H₂O; acetone / Ambient temperature

4: H₂O; tetrahydrofuran

5: CH₂Cl₂; pyridine

With diisobutylaluminium hydride; sodium cyanoborohydride; calcium carbonate; methyl iodide; In tetrahydrofuran; pyridine; 1,2-dimethoxyethane; dichloromethane; water; acetone;
DOI:10.1016/S0040-4039(01)90397-1