42-epi-(tetrazolyl)-rapamycin

Base Information

• Chemical Name: 42-epi-(tetrazolyl)-rapamycin
• CAS No.: 221877-56-1
• Molecular Formula: C₅₂H₇₉N₅O₁₂
• Molecular Weight: 966.226

Synonyms:

Chemical Property of 42-epi-(tetrazolyl)-rapamycin

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
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Technology Process of 42-epi-(tetrazolyl)-rapamycin

There total 8 articles about 42-epi-(tetrazolyl)-rapamycin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

40-(R)-trifluoromethanesulfonylrapamycin + 1H-tetrazole (288-94-8) → 42-epi-(tetrazolyl)-rapamycin (221877-56-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In Isopropyl acetate; for 18h;

Reference yield:

1H-tetrazole (288-94-8) + C52H78F3NO15S → 42-(1-tetrazoyl)-rapamycin + 42-(2-tetrazoyl)-rapamycin (221877-56-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In Isopropyl acetate; for 18h;

Reference yield:

1H-tetrazole (288-94-8) + C58H85NO15S (146903-47-1) → 40-epi-(N1-tetrazolyl)-rapamycin + 42-(2-tetrazolyl)-rapamycin (221877-56-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; at 25 ℃; for 6h;

upstream raw materials:

1H-tetrazole

sirolimus

C₅₈H₈₅NO₁₅S

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