benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

Base Information

• Chemical Name: benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate
• CAS No.: 113457-87-7
• Molecular Formula: C₄₆H₄₁N₅O₈
• Molecular Weight: 791.86
• Mol file: 113457-87-7.mol

Synonyms:

Chemical Property of benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

There total 5 articles about benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

trimethylsilyl isocyanate (1118-02-1) + benzyl 4-benzyloxy-3-<(4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-86-6) → benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-87-7)

Guidance literature:

In 1,2-dichloro-ethane;

DOI:10.1016/S0040-4039(00)96312-3

Reference yield:

methyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (102357-93-7) → benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-87-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 93 percent / KOH / H₂O; methanol / 1 h / Heating

2: 73 percent / CMC / CH₂Cl₂; dimethylformamide / Ambient temperature

3: 74 percent / sodium cyanoborohydride / acetic acid / 1 h / Ambient temperature

4: 71 percent / 1,2-dichloro-ethane / Ambient temperature

With potassium hydroxide; sodium cyanoborohydride; In methanol; dichloromethane; water; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

Reference yield:

4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid (113457-84-4) → benzyl 4-benzyloxy-3-<(4-benzyloxy-3-carbamoyl-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate (113457-87-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 73 percent / CMC / CH₂Cl₂; dimethylformamide / Ambient temperature

2: 74 percent / sodium cyanoborohydride / acetic acid / 1 h / Ambient temperature

3: 71 percent / 1,2-dichloro-ethane / Ambient temperature

With sodium cyanoborohydride; In dichloromethane; acetic acid; 1,2-dichloro-ethane; N,N-dimethyl-formamide;

upstream raw materials:

trimethylsilyl isocyanate

benzyl 4-benzyloxy-3-<(4-benzyloxy-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indol-7-yl)carbonyl>-1,2,3,6-tetrahydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylic acid

methyl 4-benzyloxy-3,6-dihydro-5-methoxypyrrolo<3,2-e>indole-7-carboxylate

Downstream raw materials:

6-(6-Carbamoyl-5-hydroxy-4-methoxy-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carbonyl)-5-hydroxy-4-methoxy-3,6,7,8-tetrahydro-pyrrolo[3,2-e]indole-2-carboxylic acid