(1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

Base Information

Chemical Name:(1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane
CAS No.:123107-58-4
Molecular Formula:C₂₁H₂₅NO₂
Molecular Weight:323.435
Hs Code.:

Synonyms:

Suppliers and Price of (1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

Chemical Property:

Purity/Quality:

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Technology Process of (1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

There total 29 articles about (1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3aR,5S,6R,6aR)-6-(2-Azido-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxole-5-carbaldehyde

: 123107-58-4
(1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 10 steps

1: sodium borohydride / ethanol

2: 83 percent

3: 1.) H₂, 2.)sodium acetate / 1.) 10percent Pd on carbon

4: 92 percent / aq. CF₃COOH

6: H₂O, mercuric chloride

7: NaBH₄

9: H₂ / palladium black / ethanol

10: sodium acetate

With sodium tetrahydroborate; water; hydrogen; sodium acetate; trifluoroacetic acid; mercury dichloride; palladium on activated charcoal; palladium; In ethanol;
DOI:10.1039/P19890001067

Reference yield:

: (R)-1-[(3aR,5S,6R,6aR)-6-(2-Azido-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-ethane-1,2-diol

: 123107-58-4
(1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 11 steps

1: sodium periodate

2: sodium borohydride / ethanol

3: 83 percent

4: 1.) H₂, 2.)sodium acetate / 1.) 10percent Pd on carbon

5: 92 percent / aq. CF₃COOH

7: H₂O, mercuric chloride

8: NaBH₄

10: H₂ / palladium black / ethanol

11: sodium acetate

With sodium tetrahydroborate; sodium periodate; water; hydrogen; sodium acetate; trifluoroacetic acid; mercury dichloride; palladium on activated charcoal; palladium; In ethanol;
DOI:10.1039/P19890001067

Reference yield:

: 123107-54-0
[(3aR,5S,6R,6aR)-6-(2-Azido-ethyl)-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-5-yl]-methanol

: 123107-58-4
(1S,3R,4R,5S)-3,5-Bis-benzyloxy-1-aza-bicyclo[2.2.2]octane

Guidance literature:: Multi-step reaction with 9 steps

1: 83 percent

2: 1.) H₂, 2.)sodium acetate / 1.) 10percent Pd on carbon

3: 92 percent / aq. CF₃COOH

5: H₂O, mercuric chloride

6: NaBH₄

8: H₂ / palladium black / ethanol

9: sodium acetate

With sodium tetrahydroborate; water; hydrogen; sodium acetate; trifluoroacetic acid; mercury dichloride; palladium on activated charcoal; palladium; In ethanol;
DOI:10.1039/P19890001067