2-[(4-Methylphenyl)carbamoyl]benzoic acid

Base Information

• Chemical Name: 2-[(4-Methylphenyl)carbamoyl]benzoic acid
• CAS No.: 19336-70-0
• Molecular Formula: C15H13 N O3
• Molecular Weight: 255.273
• European Community (EC) Number: 631-572-5
• NSC Number: 144235
• DSSTox Substance ID: DTXSID20301561
• Nikkaji Number: J1.508.750A
• Wikidata: Q82045659
• Mol file: 19336-70-0.mol

Synonyms:19336-70-0;2-[(4-methylphenyl)carbamoyl]benzoic acid;Benzoic acid,2-[[(4-methylphenyl)amino]carbonyl]-;NSC 144235;NSC144235;Oprea1_444319;Oprea1_797650;SCHEMBL10489953;DTXSID20301561;STK231355;AKOS001279885;NSC-144235;2-(4-Methylphenylcarbamoyl)benzoic acid;2-{[(4-methylphenyl)amino]carbonyl}benzoic acid;SR-01000197329;SR-01000197329-1;Z90311435

Chemical Property of 2-[(4-Methylphenyl)carbamoyl]benzoic acid

Chemical Property:

• Vapor Pressure: 3.31E-06mmHg at 25°C
• Boiling Point: 372.4°C at 760 mmHg
• Flash Point: 179°C
• Density: 1.295g/cm³
• XLogP3: 3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 255.08954328
• Heavy Atom Count: 19
• Complexity: 334

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)NC(=O)C2=CC=CC=C2C(=O)O

Technology Process of 2-[(4-Methylphenyl)carbamoyl]benzoic acid

There total 9 articles about 2-[(4-Methylphenyl)carbamoyl]benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

phthalic anhydride (85-44-9) + p-toluidine (106-49-0,12221-03-3) → N-p-tolyl-phthalamic acid (19336-70-0)

Guidance literature:

In chloroform; Heating;

Reference yield:

benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5) → N-p-tolyl-phthalamic acid (19336-70-0)

Guidance literature:

Multi-step reaction with 2 steps

1: acetic anhydride / Inert atmosphere

2: sodium dodecyl-sulfate / water; acetonitrile / 1 h / 20 °C / Inert atmosphere

With sodium dodecyl-sulfate; acetic anhydride; In water; acetonitrile;

Reference yield:

p-toluidine (106-49-0,12221-03-3) + benzene-1,2-dicarboxylic acid (88-99-3,73607-73-5) → N-p-tolyl-phthalamic acid (19336-70-0)

Guidance literature:

Man erwaermt das erhaltene p-Tolyl-phthalimid mit 10prozentiger Natronlauge auf dem Wasserbade;

upstream raw materials:

phthalic anhydride

p-toluidine

acetone

2-p-tolylisoindoline-1,3-dione

Downstream raw materials:

2-p-tolylisoindoline-1,3-dione

phthalic anhydride

N-(4-methylphenyl)-N'-phenylurea

N-phenyl-N'-p-tolyl-phthalamide