C₄₃H₄₈N₄O₆S

Base Information

• Chemical Name: C₄₃H₄₈N₄O₆S
• CAS No.: 177977-31-0
• Molecular Formula: C₄₃H₄₈N₄O₆S
• Molecular Weight: 748.943
• Mol file: 177977-31-0.mol

Synonyms:

Chemical Property of C₄₃H₄₈N₄O₆S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₄₃H₄₈N₄O₆S

There total 9 articles about C₄₃H₄₈N₄O₆S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

8-{Benzyloxycarbonyl-[4-oxo-2-propyl-3-(5'-propyl-2'-sulfamoyl-biphenyl-4-ylmethyl)-3,4-dihydro-quinazolin-6-yl]-amino}-octanoic acid (156483-33-9) → C43H48N4O6S (177977-31-0)

Guidance literature:

With dmap; 4-(dimethylamino)pyridine hydrochloride; dicyclohexyl-carbodiimide; In chloroform; at 90 ℃;

DOI:10.1016/0960-894X(96)00116-3

Reference yield:

benzyl chloroformate (501-53-1,94274-21-2) → C43H48N4O6S (177977-31-0)

Guidance literature:

Multi-step reaction with 5 steps

1: Et₃N, DMAP / CH₂Cl₂

2: 92 percent / LiNTMS₂ / dimethylformamide / 0 - 20 °C

3: Pd(PPh₃)4, NaOH / toluene; methanol / Heating

4: 1.) CF₃COOH, 2.) NaOH / 1.) CH₂Cl₂, anisole, 2.) THF, H₂O

5: DCC, DMAP, DMAP*HCl / CHCl₃ / 90 °C

With dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-(dimethylamino)pyridine hydrochloride; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hexamethyldisilazane; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1016/0960-894X(96)00116-3

Reference yield:

1-bromomethyl-4-bromobenzene (589-15-1) → C43H48N4O6S (177977-31-0)

Guidance literature:

Multi-step reaction with 7 steps

1: 46 percent / NaOH, BnNMe₃OH / toluene / 90 °C

2: Fe, HCl / methanol

3: Et₃N, DMAP / CH₂Cl₂

4: 92 percent / LiNTMS₂ / dimethylformamide / 0 - 20 °C

5: Pd(PPh₃)4, NaOH / toluene; methanol / Heating

6: 1.) CF₃COOH, 2.) NaOH / 1.) CH₂Cl₂, anisole, 2.) THF, H₂O

7: DCC, DMAP, DMAP*HCl / CHCl₃ / 90 °C

With hydrogenchloride; dmap; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 4-(dimethylamino)pyridine hydrochloride; N-benzyl-trimethylammonium hydroxide; iron; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; lithium hexamethyldisilazane; In methanol; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;

DOI:10.1016/0960-894X(96)00116-3

upstream raw materials:

8-{Benzyloxycarbonyl-[4-oxo-2-propyl-3-(5'-propyl-2'-sulfamoyl-biphenyl-4-ylmethyl)-3,4-dihydro-quinazolin-6-yl]-amino}-octanoic acid

benzyl chloroformate

1-bromomethyl-4-bromobenzene

6-nitro-2-propylquinazolin-4(3H)-one