1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

Base Information

Chemical Name:1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine
CAS No.:1049810-02-7
Molecular Formula:C₃₅H₃₇Cl₂N₅O
Molecular Weight:614.618
Hs Code.:

1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

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Chemical Property of 1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

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Technology Process of 1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

There total 10 articles about 1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1049809-78-0
N-(4-chloro-benzyl)-N-(4-{2-chloro-5-[1-(3-morpholin-4-yl-propyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenylethynyl}-benzyl)-2,2,2-trifluoro-acetamide

: 1049810-02-7
1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

Guidance literature:: With water; potassium carbonate; In methanol; at 20 ℃;
DOI:10.1016/j.bmcl.2012.12.014

Reference yield:

: 1049809-51-9
3-(4-chloro-3-iodo-phenyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]-pyridine-5-carboxylic acid tert-butyl ester

: 1049810-02-7
1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0 - 20 °C

2.1: Dess-Martin periodane / dichloromethane / 20 °C

3.1: acetic acid / dichloromethane

3.2: 0.5 h / 20 °C

4.1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

6.1: potassium carbonate; water / methanol / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; potassium carbonate; caesium carbonate; Dess-Martin periodane; acetic acid; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 4.1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2012.12.014

Reference yield:

: 1049809-53-1
3-(4-Chloro-3-iodo-phenyl)-1-(3-morpholin-4-yl-propyl)-1,4,6,7-tetrahydro-pyrazolo[4,3-c]pyridine-5-carboxylic acid tert-butyl ester

: 1049810-02-7
1-[4-({2-Chloro-5-[1-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridin-3-yl]phenyl}ethynyl)phenyl]-N-[(4-chlorophenyl)methyl]methanamine

Guidance literature:: Multi-step reaction with 3 steps

1: bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine / tetrahydrofuran / 20 °C

2: trifluoroacetic acid / dichloromethane / 0 - 20 °C

3: potassium carbonate; water / methanol / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; water; potassium carbonate; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; 1: |Sonogashira Cross-Coupling;
DOI:10.1016/j.bmcl.2012.12.014