2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

Base Information

Chemical Name:2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone
CAS No.:1093407-26-1
Molecular Formula:C₄₈H₄₁BrFN₉O
Molecular Weight:858.816
Hs Code.:

2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

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Chemical Property of 2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

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Technology Process of 2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

There total 11 articles about 2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1093407-55-6
2-chloro-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

: 1093407-25-0
3-bromo-6-pyrrolidin-3-yl-1-trityl-1H-pyrazolo[3,4-g]quinazoline

: 1093407-26-1
2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

Guidance literature:: With triethylamine;

Reference yield:

: 1000343-58-7
3-bromo-6-methyl-5-nitro-1H-indazole

: 1093407-26-1
2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / acetonitrile / 8 h / 70 °C

2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C

3: N,N-dimethyl-formamide / 0.33 h / 20 °C

4: hydrogenchloride; iron / ethanol; dichloromethane; water; toluene / 2 h / Heating / reflux

5: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

6: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 20 °C

7: manganese(IV) oxide / dichloromethane / 24 h / 20 °C

8: ammonium hydroxide / 1,4-dioxane; water / 1.5 h / 130 °C

9: hydrogenchloride / 1,4-dioxane / 20 °C

10: triethylamine

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; water; iron; potassium carbonate; ammonium hydroxide; triethylamine; HATU; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;

Reference yield:

: 81115-43-7
6-methyl-5-nitro-1H-indazole

: 1093407-26-1
2-[3-(3-bromo-1-trityl-1H-pyrazolo[3,4-g]quinazolin-6-yl)-pyrrolidin-1-yl]-1-{4-[4-(5-fluoro-pyrimidin-2-yl)-phenyl]-piperazin-1-yl}-ethanone

Guidance literature:: Multi-step reaction with 11 steps

1: bromine / methanol / 1 h / Heating / reflux

2: potassium carbonate / acetonitrile / 8 h / 70 °C

3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane / 85 °C

4: N,N-dimethyl-formamide / 0.33 h / 20 °C

5: hydrogenchloride; iron / ethanol; dichloromethane; water; toluene / 2 h / Heating / reflux

6: triethylamine; HATU / dichloromethane; N,N-dimethyl-formamide / 20 °C

7: sodium hydroxide; water / tetrahydrofuran; ethanol / 16 h / 20 °C

8: manganese(IV) oxide / dichloromethane / 24 h / 20 °C

9: ammonium hydroxide / 1,4-dioxane; water / 1.5 h / 130 °C

10: hydrogenchloride / 1,4-dioxane / 20 °C

11: triethylamine

With hydrogenchloride; manganese(IV) oxide; sodium hydroxide; N-Bromosuccinimide; water; bromine; iron; potassium carbonate; ammonium hydroxide; triethylamine; HATU; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; methanol; tetrachloromethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene; acetonitrile;