Technology Process of bis((R)-2-methoxy-1-phenylethyl) carbonate
There total 7 articles about bis((R)-2-methoxy-1-phenylethyl) carbonate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(R)-2-methoxy-1-phenyl-ethanol;
With
sodium hydride;
In
tetrahydrofuran;
at 20 ℃;
for 1h;
(R)-2-methoxy-1-phenylethyl-1 H-imidazole-1-carboxylate;
In
tetrahydrofuran;
for 4h;
DOI:10.1002/asia.201300115
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dmap; triethylamine / dichloromethane / 4 h / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h / 20 °C
3.1: tetrabutyl ammonium fluoride / acetonitrile
4.1: sodium hydride / tetrahydrofuran / 1 h
4.2: Darkness
5.1: hydrogenchloride / tetrahydrofuran; water / 4 h
6.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
6.2: 4 h
With
hydrogenchloride; dmap; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine;
In
tetrahydrofuran; dichloromethane; water; acetonitrile;
DOI:10.1002/asia.201300115
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl ammonium fluoride / acetonitrile
2.1: sodium hydride / tetrahydrofuran / 1 h
2.2: Darkness
3.1: hydrogenchloride / tetrahydrofuran; water / 4 h
4.1: sodium hydride / tetrahydrofuran / 1 h / 20 °C
4.2: 4 h
With
hydrogenchloride; tetrabutyl ammonium fluoride; sodium hydride;
In
tetrahydrofuran; water; acetonitrile;
DOI:10.1002/asia.201300115