C₅₀H₆₇⁽¹⁸⁾FN₈O₁₀

Base Information

• Chemical Name: C₅₀H₆₇⁽¹⁸⁾FN₈O₁₀
• CAS No.: 1476064-48-8
• Molecular Formula: C₅₀H₆₇FN₈O₁₀
• Molecular Weight: 958.13
• Mol file: 1476064-48-8.mol

Synonyms:

Chemical Property of C₅₀H₆₇⁽¹⁸⁾FN₈O₁₀

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₅₀H₆₇⁽¹⁸⁾FN₈O₁₀

There total 6 articles about C₅₀H₆₇⁽¹⁸⁾FN₈O₁₀ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-[18F]fluoro-2-deoxy-β-D-glucopyranosyl azide (1159266-05-3) + 2-({[5-(2,6-dimethoxyphenyl)-1-(4-{[{3-[hex-5-yn-1-yl(methyl)amino]propyl}(methyl)amino]carbonyl}-2-isopropylphenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid (1476064-49-9) → C50H67(18)FN8O10 (1476064-48-8)

Guidance literature:

With hydrogenchloride; copper(ll) sulfate pentahydrate; sodium L-ascorbate; In tetrahydrofuran; water; at 60 ℃; for 0.166667h; pH=7 - 8;

DOI:10.1021/jm401491e

Reference yield:

1-chloro-5-hexyne (10297-06-0) → C50H67(18)FN8O10 (1476064-48-8)

Guidance literature:

Multi-step reaction with 5 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: 24 h / -78 °C / Inert atmosphere

2.1: potassium iodide; potassium carbonate / acetonitrile / 71 h / Reflux

3.1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

4.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

5.1: copper(ll) sulfate pentahydrate; hydrogenchloride; sodium L-ascorbate / tetrahydrofuran; water / 0.17 h / 60 °C / pH 7 - 8

With hydrogenchloride; n-butyllithium; copper(ll) sulfate pentahydrate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; potassium iodide; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; hexane; water; acetonitrile;

DOI:10.1021/jm401491e

Reference yield:

N,N'-dimethyl-N-[6-(triisopropylsilyl)hex-5-ynyl]propane-1,3-diamine (1476064-43-3) → C50H67(18)FN8O10 (1476064-48-8)

Guidance literature:

Multi-step reaction with 3 steps

1: trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tri tert-butylphosphoniumtetrafluoroborate; 1,8-diazabicyclo[5.4.0]undec-7-ene / 1,4-dioxane / 0.5 h / 140 °C / Inert atmosphere; Microwave irradiation

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 3 h / 20 °C

3: copper(ll) sulfate pentahydrate; hydrogenchloride; sodium L-ascorbate / tetrahydrofuran; water / 0.17 h / 60 °C / pH 7 - 8

With hydrogenchloride; copper(ll) sulfate pentahydrate; trans-di(μ-acetato)bis[o-(di-o-tolylphosphino)benzyl]dipalladium(II); tetrabutyl ammonium fluoride; 1,8-diazabicyclo[5.4.0]undec-7-ene; sodium L-ascorbate; tri tert-butylphosphoniumtetrafluoroborate; In tetrahydrofuran; 1,4-dioxane; water;

DOI:10.1021/jm401491e

upstream raw materials:

1-chloro-5-hexyne

N,N'-dimethyl-N-[6-(triisopropylsilyl)hex-5-ynyl]propane-1,3-diamine

2-({[5-(2,6-dimethoxyphenyl)-1-(2-isopropyl-4-{[methyl(3-{methyl[6-(triisopropylsilyl)hex-5-yn-1-yl]amino}propyl)amino]carbonyl}phenyl)-1H-pyrazole-3-yl]carbonyl}amino)adamantane-2-carboxylic acid

2-[¹⁸F]fluoro-2-deoxy-β-D-glucopyranosyl azide