hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate)

Base Information

• Chemical Name: hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate)
• CAS No.: 1269806-78-1
• Molecular Formula: C₃₂H₃₄O₆
• Molecular Weight: 514.618
• Mol file: 1269806-78-1.mol

Synonyms:

Chemical Property of hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate)

There total 5 articles about hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

1,6-hexanediol (629-11-8) + 3-(2-(3-oxobut-1-ynyl)phenyl)propanoic acid (1269806-81-6) → hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate) (1269806-78-1)

Guidance literature:

With di-tert-butyl dicarbonate; magnesium chloride; In acetonitrile; at 40 - 70 ℃;

DOI:10.1021/ja109118m

Reference yield:

tert-butyl 3-(2-iodophenyl)propanoate (934601-93-1) → hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate) (1269806-78-1)

Guidance literature:

Multi-step reaction with 4 steps

1: copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride; triethylamine / tetrahydrofuran

2: oxalyl dichloride; dimethyl sulfoxide / dichloromethane

3: trifluoroacetic acid / dichloromethane

4: di-tert-butyl dicarbonate; magnesium chloride / acetonitrile / 40 - 70 °C

With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; oxalyl dichloride; di-tert-butyl dicarbonate; dimethyl sulfoxide; triethylamine; trifluoroacetic acid; magnesium chloride; In tetrahydrofuran; dichloromethane; acetonitrile; 1: Sonogashira coupling / 2: Swern oxidation / 2: Swern oxidation;

DOI:10.1021/ja109118m

Reference yield:

tert-butyl 3-(2-(3-oxobut-1-ynyl)phenyl)propanoate (934601-95-3) → hexane-1,6-diyl bis(3-(2-(3-oxobut-1-ynyl)phenyl)propanoate) (1269806-78-1)

Guidance literature:

Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane

2: di-tert-butyl dicarbonate; magnesium chloride / acetonitrile / 40 - 70 °C

With di-tert-butyl dicarbonate; trifluoroacetic acid; magnesium chloride; In dichloromethane; acetonitrile;

DOI:10.1021/ja109118m

upstream raw materials:

tert-butyl 3-(2-iodophenyl)propanoate

tert-butyl 3-(2-(3-hydroxybut-1-ynyl)phenyl)propanoate

tert-butyl 3-(2-(3-oxobut-1-ynyl)phenyl)propanoate

1,6-hexanediol