<2,4,6,6,7,15,16-²H₇>estrone

Base Information

• Chemical Name: <2,4,6,6,7,15,16-²H₇>estrone
• CAS No.: 84965-72-0
• Molecular Formula: C₁₈H₂₂O₂
• Molecular Weight: 277.316
• Mol file: 84965-72-0.mol

Synonyms:

Chemical Property of <2,4,6,6,7,15,16-²H₇>estrone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <2,4,6,6,7,15,16-²H₇>estrone

There total 8 articles about <2,4,6,6,7,15,16-²H₇>estrone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxyestra-1,3,5(10),15-tetraen-17-one (3563-25-5) → <2,4,6,6,7,15,16-2H7>estrone (84965-72-0,350820-16-5)

Guidance literature:

Multi-step reaction with 8 steps

1: 320 mg / NaBD₄ / CH₃OD / 12 h / 20 °C

2: 300 mg / pyridine / 20 °C

3: 1) CrO₃, 2) Girard-T reagent / 1) aq. HOAc, 20 deg C, 24 h, 2) EtOH, HOAc, reflux, 1 h

4: 60 mg / 5percent KOH / methanol / 12 h / 20 °C

5: NaBD₄ / CH₃OD / 12 h / 20 °C

6: 37percent DCl / D₂O / 1 h / Heating

7: 35 mg / D₂ / Pd/C / ethyl acetate / 2 h

8: 24 mg / Jones reagent

With chromium(VI) oxide; potassium hydroxide; jones reagent; diclazuril; sodium borodeuteride; Trimethylammoniumessigsaeurebetain-methylester-chlorid; deuterium; palladium on activated charcoal; In pyridine; methanol; deuteromethanol; water-d2; ethyl acetate;

DOI:10.1016/0039-128X(82)90137-4

Reference yield:

<15,16,17α-2H3>estradiol (84965-67-3) → <2,4,6,6,7,15,16-2H7>estrone (84965-72-0,350820-16-5)

Guidance literature:

Multi-step reaction with 7 steps

1: 300 mg / pyridine / 20 °C

2: 1) CrO₃, 2) Girard-T reagent / 1) aq. HOAc, 20 deg C, 24 h, 2) EtOH, HOAc, reflux, 1 h

3: 60 mg / 5percent KOH / methanol / 12 h / 20 °C

4: NaBD₄ / CH₃OD / 12 h / 20 °C

5: 37percent DCl / D₂O / 1 h / Heating

6: 35 mg / D₂ / Pd/C / ethyl acetate / 2 h

7: 24 mg / Jones reagent

With chromium(VI) oxide; potassium hydroxide; jones reagent; diclazuril; sodium borodeuteride; Trimethylammoniumessigsaeurebetain-methylester-chlorid; deuterium; palladium on activated charcoal; In pyridine; methanol; deuteromethanol; water-d2; ethyl acetate;

DOI:10.1016/0039-128X(82)90137-4

Reference yield:

<15,16,17α-2H3>-6-ketoestradiol → <2,4,6,6,7,15,16-2H7>estrone (84965-72-0,350820-16-5)

Guidance literature:

Multi-step reaction with 4 steps

1: NaBD₄ / CH₃OD / 12 h / 20 °C

2: 37percent DCl / D₂O / 1 h / Heating

3: 35 mg / D₂ / Pd/C / ethyl acetate / 2 h

4: 24 mg / Jones reagent

With jones reagent; diclazuril; sodium borodeuteride; deuterium; palladium on activated charcoal; In deuteromethanol; water-d2; ethyl acetate;

DOI:10.1016/0039-128X(82)90137-4

upstream raw materials:

<2,4,6,6,7,15,16,17α-²H₈>estradiol

3-hydroxyestra-1,3,5⁽¹⁰⁾,15-tetraen-17-one

<15,16,17α-²H₃>estradiol

<2,4,6,15,16,17α-²H₆>-6-dehydroestradiol