<5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol

Base Information

• Chemical Name: <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol
• CAS No.: 130633-29-3
• Molecular Formula: C₃₂H₄₄O₈
• Molecular Weight: 556.697
• Mol file: 130633-29-3.mol

Synonyms:

Chemical Property of <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol

There total 23 articles about <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<2-(benzyloxy)ethyl>-5,5-dimethyl-1,3-dioxane (116376-29-5) → <5(R)>-D-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol (130633-29-3,130790-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / 10percent Pd-C / ethanol / 2 h / Ambient temperature

2: 1.) NaH, TMEDA / 1.) r. t., 4h 2.) 100 - 110 deg C, 3d

With N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;

Reference yield:

2-<2-(benzyloxy)ethyl>-5,5-dimethyl-1,3-dioxane (116376-29-5) → <5(R)>-L-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol (130633-29-3,130790-89-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / H₂ / 10percent Pd-C / ethanol / 2 h / Ambient temperature

2: 1.) NaH, TMEDA / 1.) 4h r. t. 2.) 100 - 110 deg C, 3d

With N,N,N,N,-tetramethylethylenediamine; hydrogen; sodium hydride; palladium on activated charcoal; In ethanol;

Reference yield:

(R)-1-phenylethanol (1517-69-7) → <5(R)>-D-4-O-benzyl-2,3-O-isopropylidene-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-5-O-(phenylethyl)-myo-inositol (130633-29-3,130790-89-5)

Guidance literature:

Multi-step reaction with 6 steps

1: HBF₄*OEt₂ / CH₂Cl₂ / 0.5 h / Ambient temperature

2: 100 percent / Ag₂O / dimethylformamide / 64 h / Ambient temperature

3: 99 percent / Et₃N, H₂O / methanol / 72 h / Ambient temperature

4: 87 percent / m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

5: 89 percent / camphorsulphonic acid*H₂O / 16 h / Ambient temperature

6: 1.) NaH, TMEDA / 1.) r. t., 4h 2.) 100 - 110 deg C, 3d

With tetrafluoroboric acid diethyl ether; N,N,N,N,-tetramethylethylenediamine; camphor-10-sulfonic acid; water; sodium hydride; triethylamine; 3-chloro-benzenecarboperoxoic acid; silver(l) oxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

2-(2-hydroxyethyl)-5,5-dimethyl-1,3-dioxane

<3aR-<3aα,4α,5β(R),6β,7β,7aα>>-4-benzyloxy-6,7-epoxy-5-(1-phenylethoxy)-hexahydro-2,2-dimethylbenzo-1,3-dioxole

(R)-1-phenylethanol

(S)-Mandelic acid

Downstream raw materials:

L-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate)

D-6-O-<2-(5,5-dimethyl-1,3-dioxan-2-yl)ethyl>-2,3-O-isopropylidene-myo-inositol 1,4,5-tris(dibenzylphosphate)