1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

Base Information

Chemical Name:1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate
CAS No.:1609476-58-5
Molecular Formula:C₄₁H₅₈ClN₇O₁₃
Molecular Weight:892.404
Hs Code.:

1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

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Chemical Property of 1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

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Technology Process of 1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

There total 7 articles about 1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: C₃₄H₄₉ClN₂O₁₅

: 6-(4-aminomethylbenzyloxy)-9H-purin-2-amine

: 1609476-58-5
1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

Guidance literature:: In N,N-dimethyl-formamide; at 70 ℃; for 6h;
DOI:10.1002/anie.201310969

Reference yield:

: 418759-58-7
1-(4-hydroxy-5-methoxy-2-nitrophenyl)ethan-1-one

: 1609476-58-5
1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 60 °C

2: sodium tetrahydroborate / methanol; 1,4-dioxane / 2 h / 0 - 20 °C

3: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

4: N,N-dimethyl-formamide / 6 h / 70 °C

With sodium tetrahydroborate; potassium carbonate; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310969

Reference yield:

: 498-02-2
1-(3-methoxy-4-hydroxyphenyl)ethanone

: 1609476-58-5
1-(4-((24-chloro-3,6,9,12,15,18-hexaoxatetracosyl)oxy)-5-methoxy-2-nitrophenyl)ethyl (4-(((2-amino-9H-purin-6-yl)oxy)methyl)benzyl)carbamate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate / N,N-dimethyl-formamide / 16 h / 80 °C

2: nitric acid; acetic acid; acetic anhydride / 0 - 20 °C

3: acetic acid; hydrogen bromide / 1.5 h / 85 °C

4: potassium carbonate / N,N-dimethyl-formamide / 60 °C

5: sodium tetrahydroborate / methanol; 1,4-dioxane / 2 h / 0 - 20 °C

6: triethylamine / N,N-dimethyl-formamide / 0 - 20 °C

7: N,N-dimethyl-formamide / 6 h / 70 °C

With sodium tetrahydroborate; hydrogen bromide; nitric acid; acetic anhydride; potassium carbonate; acetic acid; triethylamine; In 1,4-dioxane; methanol; N,N-dimethyl-formamide;
DOI:10.1002/anie.201310969