7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide

Base Information

• Chemical Name: 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide
• CAS No.: 1574275-80-1
• Molecular Formula: C₁₇H₁₉F₃N₂O₂S₂
• Molecular Weight: 404.477
• Mol file: 1574275-80-1.mol

Synonyms:

Chemical Property of 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide

There total 4 articles about 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C19H21F3N2O3S2 (1574275-55-0) → 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide (1574275-80-1)

Guidance literature:

With potassium carbonate; In methanol; at 23 ℃; Inert atmosphere;

DOI:10.1021/ml500024s

Reference yield:

7-bromoheptanoic acid (30515-28-7) → 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide (1574275-80-1)

Guidance literature:

Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / dichloromethane / 6 h / 23 °C / Inert atmosphere

2: ethanol / 16 h / 23 °C / Inert atmosphere

3: palladium diacetate; 1,10-Phenanthroline; lithium tetrafluoroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid / N,N-dimethyl acetamide / 24 h / 100 °C / Inert atmosphere

4: potassium carbonate / methanol / 23 °C / Inert atmosphere

With lithium tetrafluoroborate; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; potassium carbonate; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; ethanol; dichloromethane; N,N-dimethyl acetamide;

DOI:10.1021/ml500024s

Reference yield:

7-bromo-N-(thiazol-2-yl)heptanamide (1574275-28-7) → 7-mercapto-N-(4-(4-(trifluoromethoxy)phenyl)thiazol-2-yl)heptanamide (1574275-80-1)

Guidance literature:

Multi-step reaction with 3 steps

1: ethanol / 16 h / 23 °C / Inert atmosphere

2: palladium diacetate; 1,10-Phenanthroline; lithium tetrafluoroborate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; acetic acid / N,N-dimethyl acetamide / 24 h / 100 °C / Inert atmosphere

3: potassium carbonate / methanol / 23 °C / Inert atmosphere

With lithium tetrafluoroborate; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; potassium carbonate; acetic acid; In methanol; ethanol; N,N-dimethyl acetamide;

DOI:10.1021/ml500024s

upstream raw materials:

7-bromoheptanoic acid

7-bromo-N-(thiazol-2-yl)heptanamide

C₁₉H₂₁F₃N₂O₃S₂

S-(7-oxo-7-(thiazol-2-ylamino)heptyl)ethanethioate