Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

Base Information

Chemical Name:Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl
CAS No.:156174-03-7
Molecular Formula:C₄₀H₅₃N₇O₁₁
Molecular Weight:807.901
Hs Code.:

Synonyms:

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Chemical Property of Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

Chemical Property:

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Technology Process of Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

There total 4 articles about Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 138323-03-2
(S)-4-benzyl-3-<(S)-2,3,4,5-tetrahydro-3-pyridazinyl>-2-oxazolidinone

: 156174-03-7
Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) dicyclohexylcarbodiimide, 2.) 4-dimethylaminopyridine / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 5 h

2: 89 percent / 30percent H₂O₂, 1 M LiOH / tetrahydrofuran; H₂O / 3 h / 0 °C

3: diphenylphosphinic azide, Et₃N / dimethylformamide / a) 0 deg C, 2 h, 2.) RT, overnight

With dmap; lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.67.2151

Reference yield:

: 138323-02-1
(S)-4-benzyl-3-<(S)-2-<1,2-bis(t-butoxycarbonyl)hydrazino>-5,5-dimethoxypentanoyl>-2-oxazolidinone

: 156174-03-7
Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

Guidance literature:: Multi-step reaction with 4 steps

1: 83 percent / TFA / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) dicyclohexylcarbodiimide, 2.) 4-dimethylaminopyridine / 1.) CH₂Cl₂, 0 deg C, 20 min, 2.) CH₂Cl₂, a) 0 deg C, 1 h, b) RT, 5 h

3: 89 percent / 30percent H₂O₂, 1 M LiOH / tetrahydrofuran; H₂O / 3 h / 0 °C

4: diphenylphosphinic azide, Et₃N / dimethylformamide / a) 0 deg C, 2 h, 2.) RT, overnight

With dmap; lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.67.2151

Reference yield:

: 156174-01-5
(S)-4-benzyl-3-<(S)-2-<(2S,3S)-3-(benzyloxycarbonylamino)-2-(t-butoxycarbonylamino)butanoyl>-2,3,4,5-tetrahydro-3-pyridazinylcarbonyl>-2-oxazolidinone

: 156174-03-7
Boc-Dab(Cbz)-Pya-Ala-ΔVal-Ser-OBzl

Guidance literature:: Multi-step reaction with 2 steps

1: 89 percent / 30percent H₂O₂, 1 M LiOH / tetrahydrofuran; H₂O / 3 h / 0 °C

2: diphenylphosphinic azide, Et₃N / dimethylformamide / a) 0 deg C, 2 h, 2.) RT, overnight

With lithium hydroxide; diphenylphosphoranyl azide; dihydrogen peroxide; triethylamine; In tetrahydrofuran; water; N,N-dimethyl-formamide;
DOI:10.1246/bcsj.67.2151