4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide

Base Information

• Chemical Name: 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide
• CAS No.: 116911-49-0
• Molecular Formula: C₁₈H₂₀N₂O₂
• Molecular Weight: 296.369
• Mol file: 116911-49-0.mol

Synonyms:

Chemical Property of 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide

There total 6 articles about 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-4-nitroacetanilide (712-34-5) → 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide (116911-49-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃, KI / dimethylformamide / 4 h / Ambient temperature

2: 83 percent / potassium tert-butoxide / dimethylformamide / 24 h / Ambient temperature

3: Zn, CaCl₂, C₂H₅OH, H₂O / 1.5 h / Heating

With ethanol; potassium tert-butylate; water; potassium carbonate; potassium iodide; calcium chloride; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jo00256a036

Reference yield:

3-acetamidophenyl acetate (6317-89-1) → 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide (116911-49-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 42 percent / nitric acid / 3 h / -15 - -10 °C

2: 98 percent / K₂CO₃, methanol / 5 h / Ambient temperature

3: 98 percent / K₂CO₃, KI / dimethylformamide / 4 h / Ambient temperature

4: 83 percent / potassium tert-butoxide / dimethylformamide / 24 h / Ambient temperature

5: Zn, CaCl₂, C₂H₅OH, H₂O / 1.5 h / Heating

With methanol; ethanol; potassium tert-butylate; water; nitric acid; potassium carbonate; potassium iodide; calcium chloride; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jo00256a036

Reference yield:

3-acetoxy-4-nitroacetanilide (89102-03-4) → 4-amino-3-(benzyloxy)-N-(2-propenyl)acetanilide (116911-49-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / K₂CO₃, methanol / 5 h / Ambient temperature

2: 98 percent / K₂CO₃, KI / dimethylformamide / 4 h / Ambient temperature

3: 83 percent / potassium tert-butoxide / dimethylformamide / 24 h / Ambient temperature

4: Zn, CaCl₂, C₂H₅OH, H₂O / 1.5 h / Heating

With methanol; ethanol; potassium tert-butylate; water; potassium carbonate; potassium iodide; calcium chloride; zinc; In N,N-dimethyl-formamide;

DOI:10.1021/jo00256a036

upstream raw materials:

N-(2-propenyl)-N-<3-(benzyloxy)-4-nitrophenyl>acetamide

3-hydroxy-4-nitroacetanilide

3-acetamidophenyl acetate

3-acetoxy-4-nitroacetanilide

Downstream raw materials:

N-Allyl-N-{3-benzyloxy-4-[N'-prop-(E)-ylidene-hydrazino]-phenyl}-acetamide