Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester

Base Information

• Chemical Name: Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester
• CAS No.: 205240-90-0
• Molecular Formula: C₂₀H₃₇NO₅Si
• Molecular Weight: 399.603

Synonyms:

Chemical Property of Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester

There total 19 articles about Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-2-(tert-butyldimethylsilanyloxymethyl)-2,6-dimethyl-hept-5-enal (121618-70-0,121618-62-0) → Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester (205240-90-0)

Guidance literature:

Multi-step reaction with 19 steps

1: 98 percent / sodium borohydride / ethanol / 0 °C

2: 97 percent / i-Pr₂NEt, 4-DMAP / CH₂Cl₂ / Ambient temperature

3: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

4: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

5: n-Bu₄NF / tetrahydrofuran / Ambient temperature

6: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

7: NaH / 1,2-dimethoxy-ethane / Ambient temperature

8: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

9: 85 percent / HCl, EtOH / 60 °C

10: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

11: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

12: pyridine, 4-DMAP / Ambient temperature

13: DBU / 110 °C

14: 98 percent / diisobutylaluminum hydride / tetrahydrofuran / -78 °C

15: 97 percent / pyridine, 4-DMAP / Ambient temperature

16: (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0 °C

17: -78 - 20 °C / Swern oxidn.

18: KF, 18-Crown-6 / propan-2-ol / Ambient temperature

19: 2,6-lutidine / CH₂Cl₂ / 0 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; potassium fluoride; sodium tetrahydroborate; ammonium cerium(IV) nitrate; 18-crown-6 ether; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-2,6-dimethyl-hept-5-en-1-ol (162823-45-2) → Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester (205240-90-0)

Guidance literature:

Multi-step reaction with 18 steps

1: 97 percent / i-Pr₂NEt, 4-DMAP / CH₂Cl₂ / Ambient temperature

2: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

3: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

4: n-Bu₄NF / tetrahydrofuran / Ambient temperature

5: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

6: NaH / 1,2-dimethoxy-ethane / Ambient temperature

7: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

8: 85 percent / HCl, EtOH / 60 °C

9: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

10: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

11: pyridine, 4-DMAP / Ambient temperature

12: DBU / 110 °C

13: 98 percent / diisobutylaluminum hydride / tetrahydrofuran / -78 °C

14: 97 percent / pyridine, 4-DMAP / Ambient temperature

15: (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0 °C

16: -78 - 20 °C / Swern oxidn.

17: KF, 18-Crown-6 / propan-2-ol / Ambient temperature

18: 2,6-lutidine / CH₂Cl₂ / 0 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; potassium fluoride; sodium tetrahydroborate; ammonium cerium(IV) nitrate; 18-crown-6 ether; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; N-ethyl-N,N-diisopropylamine; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

Reference yield:

tert-Butyl-((R)-2-methoxymethoxymethyl-2,6-dimethyl-hept-5-enyloxy)-dimethyl-silane (162823-46-3) → Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester (205240-90-0)

Guidance literature:

Multi-step reaction with 17 steps

1: 1.) O₃; 2.) NaBH₄ / 1.) CH₂Cl₂, -78 deg C; 2.) CH₂Cl₂, r.t.

2: Ph₃P, i-PrO₂CN=NCO₂i-Pr / tetrahydrofuran / Ambient temperature

3: n-Bu₄NF / tetrahydrofuran / Ambient temperature

4: CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

5: NaH / 1,2-dimethoxy-ethane / Ambient temperature

6: 95 percent / H₂ / Pd/C / ethanol / Ambient temperature

7: 85 percent / HCl, EtOH / 60 °C

8: 91 percent / CH₂Cl₂ / -78 - 20 °C / Swern oxidn.

9: 79 percent / lithium hexamethyldisilazide, HMPA / tetrahydrofuran / -78 °C

10: pyridine, 4-DMAP / Ambient temperature

11: DBU / 110 °C

12: 98 percent / diisobutylaluminum hydride / tetrahydrofuran / -78 °C

13: 97 percent / pyridine, 4-DMAP / Ambient temperature

14: (NH₄)2Ce(NO₃)6 / acetonitrile; H₂O / 0 °C

15: -78 - 20 °C / Swern oxidn.

16: KF, 18-Crown-6 / propan-2-ol / Ambient temperature

17: 2,6-lutidine / CH₂Cl₂ / 0 °C

With pyridine; 2,6-dimethylpyridine; hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; potassium fluoride; sodium tetrahydroborate; ammonium cerium(IV) nitrate; 18-crown-6 ether; ethanol; di-isopropyl azodicarboxylate; tetrabutyl ammonium fluoride; hydrogen; sodium hydride; diisobutylaluminium hydride; ozone; 1,8-diazabicyclo[5.4.0]undec-7-ene; triphenylphosphine; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; 1,2-dimethoxyethane; ethanol; dichloromethane; water; isopropyl alcohol; acetonitrile;

upstream raw materials:

t-butyldimethylsiyl triflate

(S)-2-(tert-butyldimethylsilanyloxymethyl)-2,6-dimethyl-hept-5-enal

(R)-2-(tert-Butyl-dimethyl-silanyloxymethyl)-2,6-dimethyl-hept-5-en-1-ol

tert-Butyl-((R)-2-methoxymethoxymethyl-2,6-dimethyl-hept-5-enyloxy)-dimethyl-silane

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 205240-90-0 Acetic acid (R)-3-[3-(tert-butyl-dimethyl-silanyloxy)-4-nitro-butyl]-3-methyl-cyclohex-1-enylmethyl ester

Send

Send

Metric Ton KG G Pound L ML

Send

Send