N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide

Base Information

• Chemical Name: N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide
• CAS No.: 908577-37-7
• Molecular Formula: C₁₈H₂₇N₅O₄
• Molecular Weight: 377.443
• Mol file: 908577-37-7.mol

Synonyms:

Chemical Property of N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide

There total 10 articles about N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Cbz-glycylalanine ethyl ester (23262-07-9) → N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide (908577-37-7)

Guidance literature:

Multi-step reaction with 11 steps

1: ethanol; hydrazine hydrate

2: aqueous HCl; NaNO₂ / 0 °C / Umsetzung des gebildeten Azids mit L-Leucin-methylester in Aether

3: ethanol; hydrazine hydrate / anfangs unter Erwaermen

4: aqueous HCl; acetic acid; NaNO₂ / 0 °C / Umsetzung des erhaltenen Azids mit L-Glutaminsaeure-dimethylester in Aethylacetat und Aether

5: aqueous methanol.NaOH / Hydrogenolyse des Reaktionsprodukts an Palladium in Essigsaeure enthaltendem wss.Methanol

6: aqueous potassium hydrogencarbonate solution

7: methanol; diethyl ether

8: ethanolic solution; hydrazine hydrate

9: aqueous hydrochloric acid; aqueous sodium nitrite solution / Erhitzen des Reaktionsprodukts mit Benzylalkohol in Xylol

10: aqueous methanol. hydrochloric acid; palladium / Hydrogenation

11: ethanol; hydrazine hydrate

With hydrogenchloride; methanol; sodium hydroxide; diethyl ether; ethanol; potassium hydrogencarbonate; hydrazine hydrate; palladium; acetic acid; sodium nitrite;

Reference yield:

benzyloxycarbonylglycyl-alanine hydrazide (23404-17-3) → N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide (908577-37-7)

Guidance literature:

Multi-step reaction with 10 steps

1: aqueous HCl; NaNO₂ / 0 °C / Umsetzung des gebildeten Azids mit L-Leucin-methylester in Aether

2: ethanol; hydrazine hydrate / anfangs unter Erwaermen

3: aqueous HCl; acetic acid; NaNO₂ / 0 °C / Umsetzung des erhaltenen Azids mit L-Glutaminsaeure-dimethylester in Aethylacetat und Aether

4: aqueous methanol.NaOH / Hydrogenolyse des Reaktionsprodukts an Palladium in Essigsaeure enthaltendem wss.Methanol

5: aqueous potassium hydrogencarbonate solution

6: methanol; diethyl ether

7: ethanolic solution; hydrazine hydrate

8: aqueous hydrochloric acid; aqueous sodium nitrite solution / Erhitzen des Reaktionsprodukts mit Benzylalkohol in Xylol

9: aqueous methanol. hydrochloric acid; palladium / Hydrogenation

10: ethanol; hydrazine hydrate

With hydrogenchloride; methanol; sodium hydroxide; diethyl ether; ethanol; potassium hydrogencarbonate; hydrazine hydrate; palladium; acetic acid; sodium nitrite;

Reference yield:

Z-Gly-L-Ala-L-Leu-OMe (62686-52-6) → N-(N-hippuroyl-L-alanyl)-L-leucine hydrazide (908577-37-7)

Guidance literature:

Multi-step reaction with 9 steps

1: ethanol; hydrazine hydrate / anfangs unter Erwaermen

2: aqueous HCl; acetic acid; NaNO₂ / 0 °C / Umsetzung des erhaltenen Azids mit L-Glutaminsaeure-dimethylester in Aethylacetat und Aether

3: aqueous methanol.NaOH / Hydrogenolyse des Reaktionsprodukts an Palladium in Essigsaeure enthaltendem wss.Methanol

4: aqueous potassium hydrogencarbonate solution

5: methanol; diethyl ether

6: ethanolic solution; hydrazine hydrate

7: aqueous hydrochloric acid; aqueous sodium nitrite solution / Erhitzen des Reaktionsprodukts mit Benzylalkohol in Xylol

8: aqueous methanol. hydrochloric acid; palladium / Hydrogenation

9: ethanol; hydrazine hydrate

With hydrogenchloride; methanol; sodium hydroxide; diethyl ether; ethanol; potassium hydrogencarbonate; hydrazine hydrate; palladium; acetic acid; sodium nitrite;

upstream raw materials:

Cbz-glycylalanine ethyl ester

Z-Gly-L-Ala-L-Leu-OMe

N-[N-(N-benzyloxycarbonyl-glycyl)-L-alanyl]-L-leucine hydrazide

benzyloxycarbonylglycyl-alanine hydrazide