((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

Base Information

Chemical Name:((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol
CAS No.:180979-42-4
Molecular Formula:C₈H₁₇NO
Molecular Weight:143.229
Hs Code.:

Synonyms:

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Chemical Property of ((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

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Technology Process of ((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

There total 5 articles about ((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 180790-14-1
(3aR,7aS)-2-Methanesulfonyl-3a,4,7,7a-tetrahydro-isoindole-1,3-dione

: 180979-42-4
((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 81 percent / H₂ / Pd/C (10percent) / ethyl acetate

2: 1.) (2-naphthyl)-substituted TADDOL / 1.) Et₂O, r.t., 3 h; 2.) THF, -50 degC, 28 d

3: 1.) LiAlH₄; 2.) sodium bis(2-methoxyethoxy)aluminium hydride / 1.) Et₂O, 0 degC, 30 min; 2.) toluene, 2 d, reflux

With lithium aluminium tetrahydride; (2-naphthyl)-substituted TADDOL; hydrogen; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1002/hlca.19960790328

Reference yield:

: 1469-48-3,565227-54-5
cis-1,2,3,6-Tetrahydrophthalimide

: 180979-42-4
((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) Et₃N / 1.) MeCN, 0 degC, 10 min; 2.) MeCN, 2.5 h

2: 81 percent / H₂ / Pd/C (10percent) / ethyl acetate

3: 1.) (2-naphthyl)-substituted TADDOL / 1.) Et₂O, r.t., 3 h; 2.) THF, -50 degC, 28 d

4: 1.) LiAlH₄; 2.) sodium bis(2-methoxyethoxy)aluminium hydride / 1.) Et₂O, 0 degC, 30 min; 2.) toluene, 2 d, reflux

With lithium aluminium tetrahydride; (2-naphthyl)-substituted TADDOL; hydrogen; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In ethyl acetate;
DOI:10.1002/hlca.19960790328

Reference yield:

: 935-79-5
cis-1,2,3,6-tetrahydrophthalic anhydride

: 180979-42-4
((1R,2S)-2-Aminomethyl-cyclohexyl)-methanol

Guidance literature:: Multi-step reaction with 5 steps

1: NH₄Cl, AcONa / acetic acid / 72 h / Heating

2: 1.) Et₃N / 1.) MeCN, 0 degC, 10 min; 2.) MeCN, 2.5 h

3: 81 percent / H₂ / Pd/C (10percent) / ethyl acetate

4: 1.) (2-naphthyl)-substituted TADDOL / 1.) Et₂O, r.t., 3 h; 2.) THF, -50 degC, 28 d

5: 1.) LiAlH₄; 2.) sodium bis(2-methoxyethoxy)aluminium hydride / 1.) Et₂O, 0 degC, 30 min; 2.) toluene, 2 d, reflux

With lithium aluminium tetrahydride; (2-naphthyl)-substituted TADDOL; hydrogen; sodium acetate; ammonium chloride; triethylamine; sodium bis(2-methoxyethoxy)aluminium dihydride; palladium on activated charcoal; In acetic acid; ethyl acetate;
DOI:10.1002/hlca.19960790328