2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

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Chemical Name:2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran
CAS No.:197647-59-9
Molecular Formula:C₄₅H₇₈O₅Si₂
Molecular Weight:755.282
Hs Code.:

2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

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Chemical Property of 2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

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Technology Process of 2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

There total 9 articles about 2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 81522-68-1
[(2Z)-2-[(3S,5R)-3,5-bis(tert-butyldimethylsilanyloxy)-2-methylenecyclohexylidene]ethyl]diphenylphosphine oxide

: 197647-48-6
(1R,3aR,7aS)-1-Isopropyl-7a-[4-methyl-4-(tetrahydro-pyran-2-yloxy)-pent-2-ynyloxymethyl]-octahydro-inden-4-one

: 197647-59-9
2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 66774-80-9,111924-49-3
(S)-2-((3R,3aR,7S,7aR)-octahydro-7-hydroxy-3a-methyl-1H-inden-3-yl)propyl 4-methylbenzenesulfonate

: 197647-59-9
2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 9 steps

1: 93 percent / LiAlH₄ / tetrahydrofuran / 21 h / Heating

2: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

3: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

4: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

5: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

6: 65 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

7: 77 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

8: 67 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

9: 41 percent

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; lithium aluminium tetrahydride; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8

Reference yield:

: 197647-61-3
20-methyl-de-A,B-pregnan-(8S)-ol

: 197647-59-9
2-(4-{(3R,3aS,7aS)-7-[2-[(3S,5R)-3,5-Bis-(tert-butyl-dimethyl-silanyloxy)-2-methylene-cyclohex-(Z)-ylidene]-eth-(E)-ylidene]-3-isopropyl-octahydro-inden-3a-ylmethoxy}-1,1-dimethyl-but-2-ynyloxy)-tetrahydro-pyran

Guidance literature:: Multi-step reaction with 8 steps

1: 88 percent / lead tetraacetate, pyridine / benzene / 3.5 h / 15 °C / Irradiation

2: 39 percent / boron trifluoride etherate / -20 deg C, 45 min, room temperature, 1 h

3: 65 percent / potassium hydroxide / methanol / 2.5 h / Heating

4: 94 percent / imidazole / dimethylformamide / 4 h / Ambient temperature

5: 65 percent / potassium hydride, 18-crown-6 / tetrahydrofuran / 0.33 h / Ambient temperature

6: 77 percent / tetra-n-butylammonium fluoride trihydrate / tetrahydrofuran / 3 h / 60 °C

7: 67 percent / pyridinium dichromate / CH₂Cl₂ / 18 h / Ambient temperature

8: 41 percent

With pyridine; 1H-imidazole; lead(IV) acetate; potassium hydroxide; dipyridinium dichromate; 18-crown-6 ether; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; potassium hydride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; benzene;
DOI:10.1016/S0968-0896(98)00161-8